FB2024_03 , released June 25, 2024
Allele: Dmel\ndl14
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General Information
Symbol
Dmel\ndl14
Species
D. melanogaster
Name
FlyBase ID
FBal0051333
Feature type
allele
Associated gene
Dmel\ndl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?1043term.

    (Stein et al., 2008)

    Has a premature stop codon prior to the ndl protease domain.

    (LeMosy and Hashimoto, 2000)

    Mutation is after the potential glycosaminoglycan addition sites and the first block of LDL-receptor ligand-binding repeats and the protein therefore does not contain the protease domain.

    (LeMosy et al., 2000)

    Nucleotide substitution: G3400A.

    (LeMosy et al., 2000)

    Amino acid replacement: W1044term.

    (LeMosy et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:6,599,367..6,599,367 [-]
    Nucleotide change:

    G6599367A

    Reported nucleotide change:

    G3400A

    Amino acid change:

    W1044term | ndl-PA

    Reported amino acid change:

    W1044term

    (LeMosy et al., 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous ndl14 follicle cell clones are produced via Scer\GAL4e22c-mediated expression of FLP recombinase. In some egg chambers all follicle cells appear to be mutant, indcating that ndl14 mutants do not confer any defect in viability or growth.

        Ventral follicle cells homozygous for the class I ndl14 allele do not perturb dorso-ventral patterning in the progeny embryos.

        (Stein et al., 2008)

        Class I allele. Affected embryos show early developmental arrest, failing to reach the cellular blastoderm stage. Eggs are very fragile, showing an "oozy eggshell" phenotype.

        (Hong and Hashimoto, 1996)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        ndl14/Df(3L)CH12 is partially rescued by ndlGAG.S-A

        (Turcotte and Hashimoto, 2002)
        Comments

        ndlGAG.S-A rescues the fragile egg/early embryo arrest phenotype of embryos laid by ndl14/Df(3L)CH12 females, but does not appreciably rescue the dorsalization phenotype of the resulting embryos.

        (Turcotte and Hashimoto, 2002)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Class I allele.

        (LeMosy et al., 2000)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        nd14
        (Shapira et al., 2011)
        ndl14
        (Stein et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (11)