FlyBase Allele Report: Dmel\w[B1-12]

General Information

Symbol

Dmel\w^B1-12

Species

D. melanogaster

Name

FlyBase ID

FBal0050914

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

P{lacW}mirr^B1-12

Carried in Construct

Also Known As

mirr-lacZ

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Choi et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{lacW}mirr^B1-12

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Singh et al., 2005, Park et al., 2002)

visible | dominant

(Choi et al., 1996)

Phenotype Manifest In

eye | ventral

(Singh et al., 2005)

pigment cell

(Singh et al., 2005, Park et al., 2002, Choi et al., 1996)

Detailed Description

Statement

Reference

Eye colour: males carrying w^B1-12 in a w^- background show pigmentation only in the dorsal half of the eye.

(Park et al., 2002)

Eye pigment distribution: dorsal domain. w⁺ eye pigment is expressed only in the dorsal domain of the eye, and pigment is slightly stronger in the anterior of the eye. Adults that escape lethality show same dorsal pattern of eye pigmentation as heterozygotes. Double mutants with pk^sple-1 show exactly the same pigment distribution as in an otherwise wild type background.

(Choi et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

w^B1-12 has abnormal eye color | male phenotype, non-enhanceable by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

NOT suppressed by

Statement

Reference

w^B1-12 has abnormal eye color | male phenotype, non-suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

w^B1-12 has pigment cell | male phenotype, non-enhanceable by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

NOT suppressed by

Statement

Reference

w^B1-12 has pigment cell | male phenotype, non-suppressible by Df(1)52/lncRNA:roX1^ex6

(Park et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Eye colour: the expression of w^B1-12 in males carrying w^B1-12 in a w^- background is unchanged if they are also carrying roX1^ex6 Df(1)52 P{w⁺4Δ4.3} (these are escaper males).

(Park et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (14)

Bloomington

78549