FB2024_03 , released June 25, 2024
Allele: Dmel\RafXS-2541
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General Information
Symbol
Dmel\RafXS-2541
Species
D. melanogaster
Name
FlyBase ID
FBal0050260
Feature type
allele
Associated gene
Dmel\Raf
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Karim and Rubin, 1998)
Mutagen
X ray
(Karim et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  carcinoma
      modeled by Ras85DV12.UAS
      (Karim and Rubin, 1998)
      modeled by Ras85DV12.ey
      (Karim and Rubin, 1998)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      RafXS-2541 is a suppressor of phenotype of Ras85DV12.ey

      (Karim and Rubin, 1998)

      RafXS-2541 is a suppressor of phenotype of Ras85DV12.sev

      (Karim et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At 25oC phlXS-2541 dominantly suppresses most of the hyperplastic growth seen in Ras85DV12.Scer\UAS Scer\GAL4dpp.blk1 wing discs. Mutation only partly suppresses the cell death and lethality associated with Ras85DV12.Scer\UAS Scer\GAL4dpp.blk1. Surviving adults have severe developmental defects. Ras85DV12.ey larvae raised at 29oC have no eye-antennal discs. These animals die as pharate adults and completely lack all head structures derived from the missing disc. Phenotype can be partially suppressed by phlXS-2541 at 29oC, most mutants have head structures, some survive to adulthood with a limited amount of hyperplasia.

      (Karim and Rubin, 1998)

      Suppresses the rough eye phenotype of Ras85DV12.sev. Enhances the phenotype of Ras85DN17.sev. Suppresses the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Enhances the aopS2382 eye phenotype.

      (Karim et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RafXS-2541
      (Karim and Rubin, 1998)
      phlXS-2541
      Name Synonyms
      Secondary FlyBase IDs
        References (2)