FB2024_03 , released June 25, 2024
Allele: Dmel\para63
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General Information
Symbol
Dmel\para63
Species
D. melanogaster
Name
FlyBase ID
FBal0050239
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Cardnell et al., 2006, Pittendrigh et al., 1997, Stern et al., 1990)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 2.2% of para63 flies become paralysed when placed at 29oC. para63 larvae exhibit a higher frequency of failures in evoked transmitter release from larval stage motor nerve terminals when bathed in varying Ca2+ concentrations. para63 larvae, at the permissive temperature of 21-22oC, exhibit compound action potentials with a reduced amplitude compared to wild-type. At the restrictive temperature of 38oC, para63 larvae exhibit a complete loss of compound action potentials. This loss is reversed when the temperature is lowered to a permissive range.

      (Huang and Stern, 2002)

      Homozygous flies do not show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies.

      (Pittendrigh et al., 1997)

      para63/paralk5 flies show temperature sensitive paralysis and reduced viability.

      (Stern et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      para63 has paralytic | heat sensitive phenotype, enhanceable by ineRA.UAS/Scer\GAL4Gli-rL82

      (Huang and Stern, 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When ineRA.Scer\UAS is expressed under the control of Scer\GAL4Gli-rL82, in a para63 mutant, 73% of the flies become paralysed at 29oC. When para63 flies, expressing ineRA.Scer\UAS under the control of Scer\GAL4Gli-rL82, are placed at 32oC, all the flies are paralysed.

      (Huang and Stern, 2002)

      Suppresses the leg shaking phenotype of Sh14.

      (Stern et al., 1990)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      para63
      (Cardnell et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)