FB2024_03 , released June 25, 2024
Allele: Dmel\gcm34
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General Information
Symbol
Dmel\gcm34
Species
D. melanogaster
Name
FlyBase ID
FBal0049596
Feature type
allele
Associated gene
Dmel\gcm
Associated Insertion(s)
P{lacZ}gcm34
Carried in Construct
Also Known As
glide/gcm34
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Laneve et al., 2013, Bernardoni et al., 1997)
Mutagen
Delta2-3 transposase
(Vincent et al., 1996)
P-element activity
(Bernardoni et al., 1997)
Progenitor genotype
gcmrA87
(Bernardoni et al., 1997, Vincent et al., 1996)
Associated Insertion(s)
P{lacZ}gcm34
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      gcm34 homozygous clones within mosaic spermathecae contain lumen epithelial cells, but completely lack secretory cells.

      (Cattenoz et al., 2016)

      The INKA cell (a peptidergic, non-neuronal cell) can not be detected in most peritracheal cell clusters in homozygous embryos, whereas the other peritracheal cells remain detectable.

      The INKA cell (a peptidergic, non-neuronal cell) can not be detected in most peritracheal cell clusters in gcm34/Df(2L)132 embryos, and in some cases other peritracheal cells in the cluster can not be detected.

      (Laneve et al., 2013)

      In gcmN7-4/gcm34 embryos many glioblasts are transformed into neuroblasts.

      (Bernardoni et al., 1999)

      gcmN7-4/gcm34 embryos have fewer hemocytes than normal, and the hemocytes show little migration compared to wild-type.

      (Bernardoni et al., 1997)

      Homozygous embryos exhibit a drastic reduction in the number of glial cells. Studies of homozygotes and transheterozygotes with gcmN7-4 demonstrate most or all glial cells are transformed into neurons. Longitudinal fibres are partially or completely interrupted in several segments and the peripheral nerves exhibit defects.

      (Vincent et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gcm34
      (Trébuchet et al., 2019, Cattenoz et al., 2016, Laneve et al., 2013)
      glide/gcm34
      (Bernardoni et al., 1999, Bernardoni et al., 1997)
      glide34
      (Vincent et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)