FlyBase Allele Report: Dmel\Taf1[S-136]

General Information

Symbol

Dmel\Taf1^S-136

Species

D. melanogaster

Name

FlyBase ID

FBal0048986

Feature type

allele

Associated gene

Dmel\Taf1

Associated Insertion(s)

Carried in Construct

Also Known As

SR3-5^S-136

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Karim et al., 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: D1041N.

(Wassarman et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,650,848..6,650,848 [+]

Nucleotide change:

G6650848A

Amino acid change:

Reported amino acid change:

D1041N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 4: DADLRR changes to DANLRR).

(Wassarman et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Wassarman et al., 2000)

lethal | recessive

(Karim et al., 1996)

Phenotype Manifest In

macrochaeta

(Wassarman et al., 2000)

Detailed Description

Statement

Reference

Taf1^EP421/Taf1^S-136 flies are have reduced bristle numbers on both male and female heads and are female sterile.

(Wassarman et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Taf1^S-136 is a suppressor of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the rough eye phenotype of Ras85D^V12.sev. Slightly suppresses the phenotype of Ras85D^N17.sev. Has little or no effect on the phenotype of phl::tor^13D.hs.sev. Suppresses the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Has little or no effect on the lethality of phl¹². Has little or no effect on the phl¹² eye phenotype. Has little or no effect on the Dsor1^XS520 eye phenotype. Has little or no effect on the aop^S2382 eye phenotype.