FlyBase Allele Report: Dmel\rl[Su23]

General Information

Symbol

Dmel\rl^Su23

Species

D. melanogaster

Name

FlyBase ID

FBal0046361

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Sawamoto et al., 1996)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1214A. Amino acid replacement: D334N. Mutation is in kinase subdomain XI.

(Lim et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:1,113,720..1,113,720 [+]

Nucleotide change:

G1113720A

Reported nucleotide change:

G1214A

Amino acid change:

Reported amino acid change:

D334N

(Lim et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | maternal effect

(Lim et al., 1999)

increased cell number | adult stage

(Lim et al., 1999)

visible | dominant

(Taguchi et al., 2000, Lim et al., 1999)

Phenotype Manifest In

embryonic abdominal segment

(Lim et al., 1999)

eye

(Lim et al., 1999)

eye photoreceptor cell

(Lim et al., 1999)

ommatidium

(Lim et al., 1999)

photoreceptor cell R7

(Sawamoto et al., 1996)

wing

(Taguchi et al., 2000, Lim et al., 1999)

wing vein

(Lim et al., 1999, Sawamoto et al., 1996)

wing vein | ectopic

(Taguchi et al., 2000)

Detailed Description

Statement

Reference

Heterozygotes have extra wing veins.

(Taguchi et al., 2000)

Heterozygotes have a mild rough eye phenotype. There are multiple R7-like cells in each ommatidium. The flies have extra wing veins. Heterozygous females show a weak dominant sterility; 10.9% of the eggs laid by these females mated to normal males fail to hatch and 15.6% of these nonviable embryos have a reduction in the number of abdominal segments. Homozygous females are essentially sterile due to defects in vitellogenesis.

(Lim et al., 1999)

Supernumerary R7 cells and extra wing veins.

(Sawamoto et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rl^Su23 has visible | dominant phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

Enhancer of

Statement

Reference

rl^Su23/rl[+] is an enhancer of visible phenotype of rg^γ3

(Shamloula et al., 2002)

NOT Enhancer of

Statement

Reference

rl^Su23 is a non-enhancer of visible phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

Suppressor of

Statement

Reference

rl^Su23/rl[+] is a suppressor of decreased occurrence of cell division | somatic clone | larval stage phenotype of Dsor1^Gp158

(Lim et al., 1999)

rl^Su23/rl[+] is a suppressor of decreased occurrence of cell division | somatic clone | larval stage phenotype of Dsor1^r1

(Lim et al., 1999)

NOT Suppressor of

Statement

Reference

rl^Su23 is a non-suppressor of visible phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

Other

Statement

Reference

rl^Su23, tor^11D has some die during embryonic stage | dominant | maternal effect | maternal effect phenotype

(Lim et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

rl^Su23 has wing phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

rl^Su23 has wing vein | ectopic phenotype, enhanceable by cln[+]/cln^SF3-2

(Taguchi et al., 2000)

rl^Su23 has wing vein phenotype, enhanceable by Df(2R)rl10b

(Lim et al., 1999)

Suppressed by

Statement

Reference

rl^Su23 has phenotype, suppressible by aos^hs.PSa

(Sawamoto et al., 1996)

Suppressor of

Statement

Reference

rl^Su23 is a suppressor of phenotype of sev^unspecified

(Lim et al., 1999)

rl^Su23/rl[+] is a suppressor of imaginal disc | somatic clone | larval stage phenotype of Dsor1^Gp158

(Lim et al., 1999)

rl^Su23/rl[+] is a suppressor of imaginal disc | somatic clone | larval stage phenotype of Dsor1^r1

(Lim et al., 1999)

rl^Su23 is a suppressor of eye phenotype of hid^GMR.PG

(Sawamoto et al., 1998)

rl^Su23 is a suppressor of eye disc phenotype of hid^GMR.PG

(Sawamoto et al., 1998)

rl^Su23 is a suppressor of phenotype of aos^hs.PSa

(Sawamoto et al., 1996)

NOT Suppressor of

Statement

Reference

rl^Su23 is a non-suppressor of embryo | posterior phenotype of fs(1)M3¹⁹⁰¹

(Lim et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The heterozygous phenotype is enhanced by one copy of cln^SF3-2.

(Taguchi et al., 2000)

Fully suppresses the phl¹ phenotype in terms of viability and the morphologies of the eye and wing veins. The extra wing vein and eye phenotypes of rl^Su23/+ flies are significantly enhanced by Df(2R)rl10b or rl¹. The posterior defects of embryos derived from homozygous fs(1)M3¹⁹⁰¹ females is not suppressed if the females are also carrying one copy of rl^Su23. Enhances the tor^11D phenotype; considerable numbers of embryos laid by females heterozygous for rl^Su23 and tor^11D fail to hatch at 28^oC. Dominantly suppresses the proliferation defects seen in homozygous phl¹, Dsor1^Gp158 or Dsor1^r1 clones in imaginal discs.

(Lim et al., 1999)

Suppresses the reduced-eye and increased cell death phenotypes of W^GMR.PG.

(Sawamoto et al., 1998)

Phenotype can be suppressed by P{hs-argos.S}.

(Sawamoto et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The mutation in rl^Su23 is identical to that found in rl^Sem.

(Lim et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rl^Su23

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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