FB2024_03 , released June 25, 2024
Allele: Dmel\bcdunspecified
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General Information
Symbol
Dmel\bcdunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0045376
Feature type
allele
Associated gene
Dmel\bcd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Following upregulation of W expression at stage 9, cells in the presumptive head and thorax regions of bcdunspecified embryos undergo cell death between stages 10 and 14. This is followed by decellularization and tissue clearance of these regions at stages 14-17. bcdunspecified larvae are missing the head and thorax and show transformation of the anterior acron into a telson.

        (Werz et al., 2005)

        Gnathal and thoracic structures are deleted in embryos derived from homozygous females, and the telson is duplicated anteriorly. Anterior abdominal segments are often fused. The cephalic fold is shifted anteriorly in embryos derived from heterozygous females.

        (Tearle and Nusslein-Volhard, 1987)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        bcdunspecified has increased cell death | embryonic stage phenotype, enhanceable by torunspecified

        (Werz et al., 2005)
        Suppressed by
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        bcdunspecified has phenotype, enhanceable by hbbcd.3UTR

        (Schulz and Tautz, 1994)
        Suppressed by
        Statement
        Reference

        bcdunspecified has phenotype, suppressible by tslunspecified/hbbcd.3UTR

        (Schulz and Tautz, 1994)
        NOT suppressed by
        Statement
        Reference

        bcdunspecified has larval head phenotype, non-suppressible by hidrvX1/Df(3L)H99

        (Werz et al., 2005)

        bcdunspecified has larval thorax phenotype, non-suppressible by hidrvX1/Df(3L)H99

        (Werz et al., 2005)
        Enhancer of
        Statement
        Reference

        bcdunspecified is an enhancer of embryo | anterior phenotype of exuunspecified

        (Tearle and Nusslein-Volhard, 1987)
        Suppressor of
        Statement
        Reference

        hbbcd.3UTR/bcdunspecified is a suppressor of phenotype of tslunspecified

        (Schulz and Tautz, 1994)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The increased cell death that occurs in the presumptive head and thorax regions of bcdunspecified embryos can be suppressed by expression of BacA\p35Scer\UAS.P\T.cWa under the control of Scer\GAL4tub, or by mutation of W, as observed in bcdunspecified, Df(3L)H99/WrvX1 double mutants. bcdunspecified, Df(3L)H99/WrvX1 double mutant larvae have an expanded first abdominal segment that is transformed into a posterior A8 identity, but still lack the head and thorax. Therefore, the transformed abdominal segment must usually undergo cell death in bcdunspecified single mutants, due to the mis-specificity of the cells within it. In torunspecified; bcdunspecified double mutant embryos, the mis-specified tissue which becomes the transformed telson in bcdunspecified single mutants undergoes decellularization and tissue clearance.

        (Werz et al., 2005)

        Enhances the exuunspecified embryonic phenotype.

        (Tearle and Nusslein-Volhard, 1987)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        bcdunspecified is rescued by bcdDronpa

        (Drocco et al., 2011)

        bcdunspecified is rescued by bcdEGFP

        (Gregor et al., 2007)

        bcdunspecified is rescued by bcdΔ

        (Wharton and Struhl, 1991)
        Not rescued by

        bcdunspecified is not rescued by bcdΔK50-57.Venus

        (Grimm and Wieschaus, 2010)
        Comments

        bcdT:Zzzz\Dronpa rescues the sterility of females homozygous for bcdunspecified.

        (Drocco et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        ems expression in embryos with different numbers of functional bcd genes has been studied.

        (Walldorf and Gehring, 1992)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        bcdunspecified
        unspecified
        (Walldorf and Gehring, 1992)
        Name Synonyms
        Secondary FlyBase IDs
          References (13)