FlyBase Allele Report: Dmel\Hsf[1]

General Information

Symbol

Dmel\Hsf¹

Species

D. melanogaster

Name

FlyBase ID

FBal0044857

Feature type

allele

Associated gene

Dmel\Hsf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Jedlicka et al., 1997)

Mutagen

ethyl methanesulfonate

(Jedlicka et al., 1997, Jedlicka et al., 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q78term.

(Jedlicka et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:18,133,091..18,133,091 [-]

Nucleotide change:

C18133091T

Amino acid change:

Q78term | Hsf-PA; Q78term | Hsf-PB; Q78term | Hsf-PC; Q78term | Hsf-PD

(Jedlicka et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response | dominant

(Baird et al., 2006)

female sterile | recessive

(Jedlicka et al., 1997)

female sterile germline-dependent | germline clone

(Chen et al., 2009)

lethal - all die before end of larval stage | recessive

(Jedlicka et al., 1997)

some die during larval stage | recessive

(Jedlicka et al., 1997)

Phenotype Manifest In

egg chamber

(Jedlicka et al., 1997)

nurse cell

(Jedlicka et al., 1997)

Detailed Description

Statement

Reference

Females from germline clones with Hsf¹ produce no or droplet eggs.

(Chen et al., 2009)

Heterozygous larvae reared in a regimen of alternating hypoxia and reoxygenation show a greatly reduced survival compared to heterozygous larvae reared in normoxia (in contrast to wild-type larvae, which show no significant difference in survival between the two rearing conditions).

(Baird et al., 2006)

No eye abnormalities are seen in Hsf¹/+.

(Berger et al., 2006)

Homozygotes arrest at the 1st or 2nd larval instar stage and die after 2-3 days without any further growth or development. Viability is rescued in homozygous or hemizygous Hsf²/Df(2R)Pcl^P2 flies carrying Hsf^+t8. Homozygous clones induced after the larval lethal stage give rise to viable populations of cells that form normal structures in the adult. Homozygous clones induced before the larval lethal stage give rise to normal structures in the abdomen, but are not recovered in the head and thorax. Females mosaic for homozygous clones in the germ line are sterile. These clones produce egg chambers which contain a single oocyte and the normal number of 15 nurse cells, but are arrested at a pre-vitellogenic stage. The DNA content of the nurse cells is somewhat lower than normal.

(Jedlicka et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsf[+]/Hsf¹ is an enhancer of visible phenotype of Scer\GAL4^ey.PB, Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}

(Berger et al., 2006)

Hsf[+]/Hsf¹ is an enhancer of abnormal size phenotype of Scer\GAL4^ey.PB, Zzzz\Poly-Ala^{A37.UAS.EGFP,Tag:NLS(SV40-largeT)}