FlyBase Allele Report: Dmel\wts[P1]

General Information

Symbol

Dmel\wts^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0044485

Feature type

allele

Associated gene

Dmel\wts

Associated Insertion(s)

P{lacW}wts^P1

Carried in Construct

Also Known As

lats^P1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Emoto et al., 2006, Mikeladze-Dvali et al., 2005)

Mutagen

Delta2-3 transposase

(Justice et al., 1995)

Progenitor genotype

P{lacW}P509-19

(Justice et al., 1995)

Associated Insertion(s)

P{lacW}wts^P1

Cytology

Description

Deletion of DNA flanking the wts^P509-19 P{lacW} insertion, probably in the proximal direction, without loss of the distal P{lacW} sequences.

(Justice et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Emoto et al., 2006)

increased cell number | larval stage

(Cho et al., 2006)

increased occurrence of cell division | embryonic stage | somatic clone

(Justice et al., 1995)

lethal | recessive

(Justice et al., 1995)

visible | recessive

(Das Thakur et al., 2010)

Phenotype Manifest In

cuticle | embryonic stage | somatic clone

(Justice et al., 1995)

eye

(Das Thakur et al., 2010)

larval dorsal multidendritic neuron ddaC | somatic clone

(Emoto et al., 2006)

photoreceptor cell R8 of pale ommatidium | increased number

(Mikeladze-Dvali et al., 2005)

photoreceptor cell R8 of yellow ommatidium

(Mikeladze-Dvali et al., 2005)

rhabdomere R8

(Mikeladze-Dvali et al., 2005)

wing disc | larval stage

(Cho et al., 2006)

Detailed Description

Statement

Reference

wts^P1 mutants produce overgrown adult eyes.

(Das Thakur et al., 2010)

The total number of photoreceptors, as well as the number of Rh5-positive and Rh6-positive photoreceptors is normal in the eyes of homozygous larvae.

(Sprecher et al., 2007)

Overgrowth is seen wts^P1 mutant wing discs collected 36-48 hours after the L2-L3 molt.

(Cho et al., 2006)

In wts^P1 mutants, ddaC dendrites are indistinguishable from wild-type controls at 24-28 hours after egg-laying. By 48-52 hours after egg laying, wts^P1 mutant dendrites tile the body wall as in wild-type. During the following 24 hours, however, wts^P1 dendrites disappear from the body wall, implying wts is required for maintenance of the already established tiling of dendrites.

(Emoto et al., 2006)

wts^P1 eyes are missing yR8 photoreceptor cells and contain an expansion of the pR8 subset. Some R8 rhabdomeres are missing altogether in these eyes but this cannot account for the complete absence of yR8 cells.

(Mikeladze-Dvali et al., 2005)

Homozygotes exhibit embryonic or early larval lethality. wts tumour phenotype in mitotic clones: overproliferation and apical hypertrophy of epithelial cells leading to abnormal deposition of cuticle.

(Justice et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

wts^P1 has increased cell number | larval stage phenotype, non-suppressible by dachs¹

(Cho et al., 2006)

NOT Enhancer of

Statement

Reference

wts^P1/wts[+] is a non-enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

wts^P1/wts[+] is a non-suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

Df(1)jub^I, wts^P1 has visible | recessive phenotype

(Das Thakur et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

wts^P1 has rhabdomere R8 phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-enhanceable by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has rhabdomere R8 phenotype, non-enhanceable by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-enhanceable by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has rhabdomere R8 phenotype, non-enhanceable by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-enhanceable by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

NOT suppressed by

Statement

Reference

wts^P1 has wing disc | larval stage phenotype, non-suppressible by dachs¹

(Cho et al., 2006)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-suppressible by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has rhabdomere R8 phenotype, non-suppressible by sev¹⁴

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-suppressible by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has rhabdomere R8 phenotype, non-suppressible by Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of yellow ommatidium phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has photoreceptor cell R8 of pale ommatidium | increased number phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

wts^P1 has rhabdomere R8 phenotype, non-suppressible by sev¹⁴/Df(3L)melt-Δ3

(Mikeladze-Dvali et al., 2005)

NOT Enhancer of

Statement

Reference

wts^P1/wts[+] is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

NOT Suppressor of

Statement

Reference

wts^P1/wts[+] is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

Df(1)jub^I, wts^P1 has eye phenotype

(Das Thakur et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A Df(1)djub^I/+ genetic background modestly affects the wts^P1 eye phenotypes.

(Das Thakur et al., 2010)

d^GC13 does not suppress the wing disc overgrowth seen in wts^P1 mutant larvae.

(Cho et al., 2006)

sev¹⁴; wts^P1 double-mutant retina show the same phenotype as wts^P1 eyes, with all R8 cells being specified as the p subtype. Df(3L)melt-Δ3, wts^P1 double mutants and sev¹⁴; Df(3L)melt-Δ3, wts^P1 triple mutants also show the wts^P1 phenotype.

(Mikeladze-Dvali et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

wts^P1 is rescued by wts^{UAS.L.Tag:MYC}/Scer\GAL4^ppk.PG

(Emoto et al., 2006)

Not rescued by

wts^P1 is not rescued by wts^{S920.T1083.UAS}/Scer\GAL4^ppk.PG

(Emoto et al., 2006)

Comments

Expression of wts^{Scer\UAS.L.T:Hsap\MYC}, under the control of Scer\GAL4^ppk.PG largely rescues the dendritic phenotype of wts^P1.

Expression of wts^{S920.T1083.Scer\UAS} under the control of Scer\GAL4^ppk.PG fails to rescue the dendritic phenotypes associated with wts^P1 mutants.

(Emoto et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

lats^P1

(Brumby et al., 2004, Tao et al., 1999)

wts^P1

(Jukam et al., 2013, Sprecher et al., 2007, Cho et al., 2006, Emoto et al., 2006)

wts^latsP1

(Mikeladze-Dvali et al., 2005)

wts^p1

(Jukam et al., 2013, Das Thakur et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (12)

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