FB2024_03 , released June 25, 2024
Allele: Dmel\binI1
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General Information
Symbol
Dmel\binI1
Species
D. melanogaster
Name
FlyBase ID
FBal0043737
Feature type
allele
Associated gene
Dmel\bin
Associated Insertion(s)
Carried in Construct
Also Known As
binl1
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Anderson et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q205term.

(Zaffran et al., 2001)

Nucleotide substitution: C?T.

(Zaffran et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:6,991,443..6,991,443 [+]
Nucleotide change:

C6991443T

Reported nucleotide change:

C?T

Amino acid change:

Q205term | bin-PA

Reported amino acid change:

Q205term

(Zaffran et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In binI1 stage 17 embryos, the testes often exhibit dispersed aggregates of germline niche cells, unlike the single anterior niche position in controls.

      (Anllo and DiNardo, 2022)

      Homozygous embryos show defects in the normal left-right asymmetry of the anterior midgut, with many showing either inversion of the normal asymmetry or no left-right asymmetry.

      (Taniguchi et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      binR22/binI1 is partially rescued by Scer\GAL4bap.3/binUAS.cZa

      (Zaffran et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (11)