FlyBase Allele Report: Dmel\neb[Mot]

General Information

Symbol

Dmel\neb^Mot

Species

D. melanogaster

Name

FlyBase ID

FBal0042671

Feature type

allele

Associated gene

Dmel\neb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Ruden et al., 1997)

Mutagen

ethyl methanesulfonate

(Ruden et al., 1997, Ruden et al., 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: N952E. N952 falls in the putative cargo-binding domain.

(Ruden et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Ruden et al., 1997)

lethal | embryonic stage | maternal effect | recessive

(Ruden et al., 1997)

lethal | recessive

(Ruden and Jäckle, 1995)

partially lethal - majority die | larval stage | recessive

(Ruden et al., 1997)

Phenotype Manifest In

embryonic abdomen | maternal effect

(Ruden et al., 1997)

interommatidial bristle | maternal effect

(Ruden et al., 1997)

macrochaeta | maternal effect

(Ruden et al., 1997)

wing | maternal effect

(Ruden et al., 1997)

Detailed Description

Statement

Reference

Shows a maternal-effect bicaudal phenotype. Escapers have many missing bristles, behavioural defects and wings held out perpendicular to the body.

(Ruden et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

neb^Mot has embryonic abdomen phenotype, enhanceable by stau²

(Ruden et al., 1997)

Enhancer of

Statement

Reference

neb^Mot is an enhancer of embryonic abdomen phenotype of stau²

(Ruden et al., 1997)

Suppressor of

Statement

Reference

neb^Mot is a suppressor of phenotype of kni^unspecified

(Ruden et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Maternal-effect bicaudal phenotype is enhanced if mothers are also mutant for stau².

(Ruden et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

A background recessive lethal mutation found on the kni³ chromosome (removed by genetic recombination).

(Ruden and Jäckle, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Klp38B^Mot

Mot¹

Mothra¹

klp38B¹

(Ruden et al., 1997)

neb^Mot

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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