FB2024_03 , released June 25, 2024
Allele: Ecol\lacZftz.PB
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General Information
Symbol
Ecol\lacZftz.PB
Species
E. coli
Name
FlyBase ID
FBal0041451
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{ftz-lacB}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hiromi and Gehring, 1987, Hiromi et al., 1985)
Progenitor genotype
Carried in construct
P{ftz-lacB}
Cytology
Description

lacZ reporter expression is driven by a deletion fragment of the ftz promoter that includes the zebra and neurogenic element.

(Hiromi et al., 1985)
Allele components
Component
Use(s)
Regulatory region(s)
ftz_lacB
ftz_neurogenic_enhancer
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      No Assay Recorded
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 6 -- 17
      organism | pair rule expression pattern
      (Hiromi et al., 1985)
      embryonic stage 11 -- 17
      neuroblast | restricted
      (Hiromi et al., 1985)
      embryonic stage 13 -- 17
      larval ventral nerve cord | segmentally repeated
      (Hiromi et al., 1985)
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage
      epidermis | segmentally repeated
      (Goriely et al., 1991)
      larval ventral nerve cord | segmentally repeated
      (Goriely et al., 1991)
      embryonic stage 10 -- 11
      mesoderm | pair rule expression pattern
      (Hiromi and Gehring, 1987)
      embryonic stage 15 -- 16
      presumptive embryonic/larval central nervous system
      (Hiromi and Gehring, 1987)
      Additional Information
      Statement
      Reference

      Expression in epidermis in a weak striped pattern.

      (Goriely et al., 1991)

      In germ-band extended embryos, strong expression in the mesoderm, but characteristic ftz expression in the ectoderm is greatly reduced. Expressed in even parasegments. In later embryos, expression is observed in the CNS.

      (Hiromi and Gehring, 1987)

      In gastrulating embryos, two weaker stripes observed anterior to the cephalic furrow (unlike wild-type ftz pattern). During mid-embryogenesis expression also observed in pairs of large cells; assumed to be neuroblasts. Expression throughout the ventral nerve cord (not in pair-rule pattern). Very weak epidermal expression.

      (Hiromi et al., 1985)
       
      Marker for
      Reflects expression of
      ftz
      (Goriely et al., 1991, Hiromi and Gehring, 1987, Hiromi et al., 1985)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (33)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ecol\lacZftz.PB
      lacZftz.PB
      Name Synonyms
      Secondary FlyBase IDs
        References (4)