FB2024_03 , released June 25, 2024
Allele: Dmel\repo00692
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General Information
Symbol
Dmel\repo00692
Species
D. melanogaster
Name
FlyBase ID
FBal0039827
Feature type
allele
Associated gene
Dmel\repo
Associated Insertion(s)
P{PZ}repo00692
Carried in Construct
Also Known As
repo2
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Xiong et al., 1994)

loss of function allele

(Halter et al., 1995)
Mutagen
P-element activity
(Schmidt et al., 1997, Campbell et al., 1994, Xiong et al., 1994)
Progenitor genotype
Associated Insertion(s)
P{PZ}repo00692
Cytology
Description

Contrary to that reported in FBrf0074834, P{PZ} is inserted between base pairs 202 and 203 of the published sequence (FBrf0074834), in the 5' UTR, in opposite orientation to the repo transcript.

(Halter et al., 1995)

P-element insertion, in the opposite direction to repo transcription, within an intron.

(Xiong et al., 1994)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Late stage 14 embryos show disruptions in the axon scaffold. The projections of the VUM neurons are particularly affected. PNS phenotype is much weaker. AT later stages fibers are partially defasciculated. In mutant embryos of stage 17 the VNC remains extended to various degrees. The surface of the VNC in all mutant embryos has a very rough and loosely packed appearance. At the end of stage 12, the MM-CBG prematurely stop migrating. At this stage the number of glia in the VNC is wild type, but by stage 16 the total number of glial cells in the CNS is reduced.

      (Halter et al., 1995)

      Heterozygotes with repo1 are lethal. Df(3R)P14 heterozygous embryos at stage 15 have thin longitudinal tracts in some segments due to poor condensation (may be due to another gene within Df(3R)P14).

      (Xiong et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      repo03702

      (BDGP Project Members, 1994-1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      (Xiong et al., 1994)
      Comments
      Comments

      Remobilisation of the P{PZ} generates viable revertants.

      (Halter et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(3)00692
      (Spradling et al., 1999)
      repo00692
      repo2
      (Schmidt et al., 1997, Halter et al., 1995)
      repo3
      (Xiong et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)