FB2024_03 , released June 25, 2024
Allele: Dmel\PCNA157
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General Information
Symbol
Dmel\PCNA157
Species
D. melanogaster
Name
FlyBase ID
FBal0039660
Feature type
allele
Associated gene
Dmel\PCNA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: Y249N. The identified nucleotide substitutions are probably strain-specific polymorphisms. Nucleotide substitution: G52A. Nucleotide substitution: A216T. Nucleotide substitution: T253C. Nucleotide substitution: C317T. Nucleotide substitution: T329C. Nucleotide substitution: A542G.

(Henderson et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:20,261,917..20,261,917 [-]
Nucleotide change:

T20261917A

Amino acid change:

Y249N | PCNA-PA; Y249N | PCNA-PB

Reported amino acid change:

Y249N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Other polymorphisms present in strain but are unlikely to be cause of mutant phenotype.

(Henderson et al., 2000, Yamaguchi et al., 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes die as embryos or first instar larvae.

      (Henderson et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      PCNA36

      (Henderson et al., 2000)
      Comments

      non-complementing

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      M(2)173157
      (Shellenbarger and Duttagupta, 1978)
      PCNA157
      l(2)157
      l(2)56Fa2
      mus209157
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0009105
      References (3)