FlyBase Allele Report: Dmel\klar[marb-BX3]

General Information

Symbol

Dmel\klar^marb-BX3

Species

D. melanogaster

Name

FlyBase ID

FBal0039638

Feature type

allele

Associated gene

Dmel\klar

Associated Insertion(s)

Carried in Construct

Also Known As

klar^mBX3

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Mosley-Bishop et al., 1999, Fischer-Vize and Mosley, 1994)

Mutagen

X ray

(Fischer-Vize and Mosley, 1994)

Progenitor genotype

Caused by aberration

In(3LR)marb^BX3

Cytology

Description

Contains an inversion after residue 1598 of the klar coding region.

(Guo et al., 2005)

A lesion exists in the fourth exon of the klar open reading frame.

(Mosley-Bishop et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Mosley-Bishop et al., 1999)

visible

(Mosley-Bishop et al., 1999)

visible | recessive

(Fischer-Vize and Mosley, 1994)

Phenotype Manifest In

cone cell

(Mosley-Bishop et al., 1999)

eye

(Mosley-Bishop et al., 1999, Fischer-Vize and Mosley, 1994)

eye disc & nucleus | ectopic

(Patterson et al., 2004)

lipid droplet

(Guo et al., 2005, Welte et al., 1998)

presumptive embryonic salivary gland

(Myat and Andrew, 2002)

rhabdomere & nucleus

(Mosley-Bishop et al., 1999)

Detailed Description

Statement

Reference

klar^marb-BX3 embryos show aberrant lipid droplet transport.

(Guo et al., 2005)

In klar^marb-BX3/Df(3L)emc-E12 mutant eye discs, the R-cell nuclei are abnormally basal, instead of being exclusively apical as in wild type. In these discs, even though most of the nuclei are basal, the microtubule organising centres are apical.

(Patterson et al., 2004)

The size of the salivary gland lumen is reduced in homozygous embryos.

(Myat and Andrew, 2002)

Homozygotes exhibit a rough eye phenotype. R-cell nuclei fail to migrate apically, as in wild-type, but fall beneath the basal membrane into the axons of the R-cells. The R-cells remain basal posterior to the morphogenetic furrow. The cone cells, however do migrate apically, but not all of them reach the apical surface as seen in wild-type.

(Mosley-Bishop et al., 1999)

Homozygotes show defects in lipid droplet transport.

(Welte et al., 1998)

Rough eye phenotype.

(Fischer-Vize and Mosley, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

klar¹

(Welte et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25096

bw¹; klar^marb-BX3 st¹/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

klar^MBX3

(Myat and Andrew, 2002)

klar^mBX3

(Guo et al., 2005, Patterson et al., 2004, Mosley-Bishop et al., 1999)

klar^marb-BX3

kls^marb-BX3

marb^BX3

(Welte et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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