FB2024_03 , released June 25, 2024
Allele: Dmel\sunEM67
Open Close
General Information
Symbol
Dmel\sunEM67
Species
D. melanogaster
Name
FlyBase ID
FBal0039471
Feature type
allele
Associated gene
Dmel\sun
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Katzen and Bishop, 1996, Katzen, 1990)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The sunEM67/sunEM69 combination gives fertile females at a rate of 10%. Mutant larvae show greatly delayed larval growth.

      (Kidd et al., 2005)

      sunEM67/+ female flies exhibit an extended lifespan compared with the parental strain (25% increase in average lifespan). At day 6, mortality is minimal for both parental and sunEM67/+ females. At day 30, the mortality rate diverges significantly between parental and sunEM67/+ females. No difference in ATP concentrations is observed between the parental and sunEM67/+ mutant females. As compared to the parental strain, sunEM67/+ females exhibit an increase in resistance to 20mM dietary paraquat (a free radical generator).

      (Cvejic et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      sunEM67 is rescued by sun+t11.6

      (Cvejic et al., 2004)

      sunEM67 is rescued by sun+t11.6

      (Katzen, 1990)
      Comments

      The increase in lifespan observed in sunEM67/+ females can be rescued by sun+t11.6.

      (Cvejic et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The sunEM67 chromosome may carry a second lethal mutation; attempts to produce germ-line clones by X-ray induced mitotic recombination has not resulted in any females that are able to lay eggs.

      (Kidd et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      em67
      (Katzen and Bishop, 1996)
      l(1)13FeEM67
      sun4
      (Kidd et al., 2005)
      sunEM67
      Name Synonyms
      Secondary FlyBase IDs
        References (4)