FlyBase Allele Report: Dmel\grp[unspecified]

General Information

Symbol

Dmel\grp^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0039379

Feature type

allele

Associated gene

Dmel\grp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

radiation resistant

(Royou et al., 2005)

Phenotype Manifest In

centrosome

(Sibon et al., 2000)

embryo | embryonic cycle 13

(Sibon et al., 2000)

embryo | embryonic stage 4

(Fogarty et al., 1994)

interphase & organism | embryonic cycle 11 | maternal effect

(Merkle et al., 2009)

interphase & organism | embryonic cycle 12 | maternal effect

(Merkle et al., 2009)

interphase & organism | embryonic cycle 13 | maternal effect

(Merkle et al., 2009)

midbody

(Fogarty et al., 1994)

mitotic domain 1 | embryonic cycle 12

(Fogarty et al., 1994)

spindle

(Sibon et al., 2000)

Detailed Description

Statement

Reference

Embryos derived from grp^unspecified females have significantly shorter interphases during cycles 11, 12 and 13 compared to wild-type or lok^p6 single mutant embryos.

(Merkle et al., 2009)

When exposed to increasing levels of X ray irradiation mutant animals exhibit similar levels of lethality to wild-type. However no decrease in mitotic index is seen in mutants, in contrast to wild-type, which show a gradual reduction of mitotic index with increasing X ray dose. Mutants also exhibit a slightly suppressed reduction of the frequency of anaphase seen when wild-type animals are exposed to increasing does ox X ray.

(Royou et al., 2005)

No precocious anaphases are seen in grp^unspecified mutants.

(McKim et al., 2000)

In embryos derived from homozygous females mated to wild-type males, microtubule organisation is indistinguishable from that of wild-type embryos through the first 11 divisions. During mitosis 12, the spindles are somewhat shorter than wild type and the centrosomal foci are somewhat weaker than normal, but microtubule organisation during interphase following mitosis 12 appear normal. During mitosis 13 the centrosomal foci become essentially undetectable and anastral spindles with broad poles are formed. The chromosomes do not form a compact mass at the metaphase plate. Mitosis 13 is prolonged. On exit from mitosis 13, centrosomal foci reappear and organise interphase microtubule arrays.

(Sibon et al., 2000)

After interphase cycle 12, grp-derived embryos begin to exhibit an uneven nuclear distribution and irregular shaped nuclei. This phenotype becomes more extreme as the nuclei form distinct clusters. Cellularization does not occur. Abnormal nuclei do not recede into the interior. Fusion of sister nuclei occurs during telophase of nuclear cycle 12, and midbody formation is abnormal. Embryos arrest in cycle 13 with their chromosomes encompassed by spindles. Unusually, X irradiation induces metaphase arrest at all syncytial cycles.

(Fogarty et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

grp^unspecified is a non-enhancer of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-enhancer of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

NOT Suppressor of

Statement

Reference

grp^unspecified is a non-suppressor of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-suppressor of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

grp^unspecified is a non-enhancer of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-enhancer of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-enhancer of phenotype of png^unspecified

(Lee et al., 2001)

NOT Suppressor of

Statement

Reference

grp^unspecified is a non-suppressor of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-suppressor of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

grp^unspecified is a non-suppressor of phenotype of png^unspecified

(Lee et al., 2001)

Other

Statement

Reference

grp^unspecified, mei-9^a has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

grp^unspecified, BubR1^unspecified double mutants exhibit a mitotic index similar to BubR1^unspecified when not irradiated, but do not exhibit as great a X ray dose dependent reduction in mitotic index as seen in BubR1^unspecified.

(Royou et al., 2005)

When mei-9^a is added to either grp^unspecified or grp^unspecified/+ flies, precocious anaphases are sometimes seen.

(McKim et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

grp^unspecified

unspecified

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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