FlyBase Allele Report: Dmel\Scm[Suz302]

General Information

Symbol

Dmel\Scm^Suz302

Species

D. melanogaster

Name

FlyBase ID

FBal0039014

Feature type

allele

Associated gene

Dmel\Scm

Associated Insertion(s)

Carried in Construct

Also Known As

Su(z)302, Scm^Su(z)302

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Cheng et al., 1994)

hypomorphic allele - genetic evidence

(Bornemann et al., 1998)

Mutagen

ethyl methanesulfonate

(Bornemann et al., 1998)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G to A. Amino acid replacement: D215N. D215N lies within the first of the two mbt repeats.

(Bornemann et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,636,455..9,636,455 [-]

Nucleotide change:

G9636455A

Reported nucleotide change:

G?A|FBrf0104734

Amino acid change:

D215N | Scm-PA; D215N | Scm-PB

Reported amino acid change:

D215N|FBrf0104734

(Bornemann et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Scm^Suz302/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{wA}4-4. Scm^Suz302/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-31.

(Boivin et al., 2003)

Pairing sensitive repression is alleviated in iab-7 PRE lines that carry Scm^Suz302.

(Hagstrom et al., 1997)

In z¹ w^zm strain mutation causes reduction of eye pigmentation.

(Georgiev, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scm^Suz302 is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Bornemann et al., 1998)

Scm^Suz302 is an enhancer of partially lethal | dominant phenotype of Pc³

(Bornemann et al., 1998)

Suppressor of

Statement

Reference

Scm^Suz302/Scm[+] is a suppressor of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Scm^Suz302 is a suppressor of visible phenotype of ct^pN2s

(Melnikova et al., 1996)

Scm^Suz302 is a suppressor of visible phenotype of ct^n2s

(Melnikova et al., 1996)

Other

Statement

Reference

Scm^Suz302/Scm^D1, Sfmbt¹ has neoplasia | somatic clone phenotype

(Grimm et al., 2009)

Sce^D1, Scm^Suz302 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Scm^Suz302, ph-p⁴⁰⁹ has partially lethal phenotype

(Bornemann et al., 1998)

Pc², Scm^Suz302 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scm^Suz302 is an enhancer of phenotype of Pc¹⁵

(Bornemann et al., 1998)

Suppressor of

Statement

Reference

Scm^Suz302/Scm[+] is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Scm^Suz302 is a suppressor of phenotype of z¹

(Bornemann et al., 1998)

Scm^Suz302 is a suppressor of wing phenotype of ct^pN2s

(Melnikova et al., 1996)

Scm^Suz302 is a suppressor of wing phenotype of ct^n2s

(Melnikova et al., 1996)

Other

Statement

Reference

Scm^Suz302/Scm^D1, Sfmbt¹ has wing disc | somatic clone phenotype

(Grimm et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Sfmbt¹ Scm^D1/Scm^Suz302 double mutant clones in the wing disc have a tumour-like phenotype that is characterized by unrestricted cell proliferation (this phenotype is not seen in single mutant clones).

(Grimm et al., 2009)

Scm^Suz302 suppresses the pairing-dependent silencing of w^{enh.iab-7PRE.410} seen in flies homozygous for P{iab-7PRE-w^enh.410}1 or P{iab-7PRE-w^enh.410}2. Scm^Suz302 suppresses the pairing-dependent silencing of w^{enh.iab-7PRE.260} seen in flies homozygous for P{iab-7PRE-w^enh.260}1 or P{iab-7PRE-w^enh.260}2.

(Mishra et al., 2001)

Dominantly enhances the homeotic phenotypes of Pc³/+ adults. Partially lethal in double heterozygous combination with Pc³, Pc² or Sce^D1. ph-p⁴⁰⁹ males that are also heterozygous for Scm^Suz302 show partial lethality.

(Bornemann et al., 1998)

Has no effect on the phenotypes of ct^2s, ct^4s and ct⁶, where the wing margin enhancer is completely blocked.

(Melnikova et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Scm⁴

(Bornemann et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Scm³⁰²

(Gildea et al., 2000)

Scm^D215N

(Grimm et al., 2009)

Scm^Su(z)302

(Grimm et al., 2009, Boivin et al., 2003)

Scm^Suz302

Su(z)302

(Belenkaya et al., 1998, Bornemann et al., 1998, Sinclair et al., 1998, Hagstrom et al., 1997, Melnikova et al., 1996, Cheng et al., 1994, Georgiev, 1994)

Name Synonyms

Secondary FlyBase IDs

References (11)

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