FlyBase Allele Report: Dmel\wg[S84]

General Information

Symbol

Dmel\wg^S84

Species

D. melanogaster

Name

FlyBase ID

FBal0036004

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

temperature conditional amorphic allele - genetic evidence

cold sensitive antimorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

cold sensitive antimorphic allele - genetic evidence

(Couso and Martinez Arias, 1994)

temperature conditional amorphic allele - genetic evidence

(Couso and Martinez Arias, 1994)

Mutagen

Progenitor genotype

Cytology

Description

Deletion in the DNA encoding the carboxy-terminus of the wg protein.

(Buratovich et al., 1997)

C-terminal deletion.

(Couso and Martinez Arias, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | heat sensitive

(Couso et al., 1995)

Phenotype Manifest In

antenna

(Buratovich et al., 1997)

anterior dorsocentral bristle

(Buratovich et al., 1997)

leg

(Buratovich et al., 1997)

macrochaeta & scutum

(Buratovich et al., 1997)

microchaeta & scutum

(Buratovich et al., 1997)

proboscis

(Buratovich et al., 1997)

sternite

(Buratovich et al., 1997)

wing

(Buratovich et al., 1997)

Detailed Description

Statement

Reference

Loss of function allele at 25^oC and an antimorphic allele at 17^oC. At 17^oC wg^Sp-1/wg^S84 flies are wild type. Combination of wg^spd-fg wg^S84 at 25^oC causes alular etching. At 17^oC this etching phenotype is enhanced and causes loss of ventral structures, truncations and complete loss of legs. wg^spd-fg wg^Sp-m2/wg^S84 flies shifted to 17^oC postembryonically exhibit further wing etching, leg disturbances, loss of terminal structures of the proboscis, macrochaetes and microchaetes on the notum, one or both antenna and abdominal sternites. wg^spd-fg wg^Sp-1/wg^S84 flies shifted to 17^oC postembryonically also show enhancement of the wing etching phenotype, occasional loss of one or both antennae and dorsocentral rows of microchaetes, occasional sternites are missing but no sign of either the leg phenotypes or the aDC macrochaetae loss. At 25^oC wg^Sp-1/wg^S84 and wg^spd-fg wg^Sp-1/wg^S84 flies lose aDC macrochaetes.

(Buratovich et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

wg^S84 is an enhancer of phenotype of Ser^CS94

(Couso et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Dominant enhancer of Ser null mutations at 17^oC, flies die as pupae with nicks in the wing margin.

(Couso et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Protein is secreted. Antimorphic at 17^oC, null at 25^oC. Has an antimorphic effect on N at 17^oC. Shows strong allele-specific interaction with N^nd-2, and no interaction with N^M1.

(Couso and Martinez Arias, 1994)

Null at 25^oC and an antimorph at 17^oC.

(Couso et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

wg^S84

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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