FB2024_03 , released June 25, 2024
Allele: Dmel\twe+t10
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General Information
Symbol
Dmel\twe+t10
Species
D. melanogaster
Name
FlyBase ID
FBal0035878
Feature type
allele
Associated gene
Dmel\twe
Associated Insertion(s)
Carried in Construct
P{twe+10.0}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Alphey et al., 1992)
wild_type
(Alphey et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Alphey et al., 1992)
wild_type
(Alphey et al., 1992)
Mutagen
in vitro construct
(Alphey et al., 1992)
Progenitor genotype
Carried in construct
P{twe+10.0}
Cytology
Description

Contained within a 10kb genomic EcoRI fragment.

(Alphey et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
twe
Encoded product / tool
twe
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:16,257,197..16,267,662 [-]
Linked to:
EcoRI-EcoRI restriction fragment
Comment:

position of restriction fragment on reference sequence inferred by FlyBase curator

Comment:

rescue fragment

(Alphey et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In a small proportion of embryos with two copies of twe+t10, there is an additional mitosis prior to cellularization. A high proportion (almost 90%) of Df(3L)BK10 mutant embryos with two copies of twe+t10 have an extra (14th) cleavage division prior to cellularization.

      (Großhans et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Extra copies of twe+t3.7 or twe+t10 or combinations thereof, enhance the mitotic cycle phenotype seen in Cdk7D137R.Scer\UAS.T:Ivir\HA1 or Cdk7T170A.Scer\UAS.T:Ivir\HA1 flies, when driven by Scer\GAL4Kr.PM, in a dose dependant manner.

      (Leclerc et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      twe+t10 rescues tweunspecified

      (Ashburner et al., 1999)

      twe+t10 rescues twe1

      (Alphey et al., 1992)
      Fails to rescue

      twe+t10 fails to rescue In(2L)el18/Df(2L)RN2

      (Ashburner et al., 1999)
      Comments

      Rescues the sterility of twe alleles. Fails to rescue the lethality of In(2L)el18/Df(2L)RN2.

      (Ashburner et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      twe+t10
      Name Synonyms
      Secondary FlyBase IDs
        References (5)