FB2024_03 , released June 25, 2024
Allele: Dmel\timL1
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General Information
Symbol
Dmel\timL1
Species
D. melanogaster
Name
FlyBase ID
FBal0035779
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Rothenfluh-Hilfiker et al., 1995)
Mutagen
ethyl methanesulfonate
(Rothenfluh et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: K586M.

(Rothenfluh et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:3,502,495..3,502,495 [-]
Nucleotide change:

A3502495T

Amino acid change:

K586M | tim-PB; K586M | tim-PL; K586M | tim-PM; K586M | tim-PN; K586M | tim-PO; K586M | tim-PP; K554M | tim-PR; K554M | tim-PS; K609M | tim-PT; K586M | tim-PU

Reported amino acid change:

K586M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rothenfluh et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes have a locomotion period of 27.8 +/- 0.2 hours. Heterozygotes have a locomotion period of 25.5 +/- 0.1 hours. The mutant flies show temperature compensation of the locomotion period. The transition point of the phase response curve is delayed in timL1 flies, to about ZT 19.5 (compared to about ZT 18.5 in wild type). The amplitude of the advance domain is more than double that seen in wild-type flies.

      (Rothenfluh et al., 2000)

      Mutation produces 26.7 hour circadian rhythms in homozygotes and 25.4 circadian rhythm in heterozygotes.

      (Rothenfluh-Hilfiker et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tim01

      (Rothenfluh et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Long circadian period mutant.

      (Rothenfluh-Hilfiker et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      timL1
      (Singh et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)