FlyBase Allele Report: Dmel\nanos[bcd.3UTR]

General Information

Symbol

Dmel\nanos^bcd.3UTR

Species

D. melanogaster

Name

FlyBase ID

FBal0035302

Feature type

allele

Associated gene

Dmel\nanos

Associated Insertion(s)

Carried in Construct

P{nanos-bcd3'UTR}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Gavis and Lehmann, 1994, Gavis and Lehmann, 1992)

Progenitor genotype

Carried in construct

P{nanos-bcd3'UTR}

Cytology

Description

Construct: nos 3' untranslated region (3'UTR) is replaced by bcd 3'UTR.

(Gavis and Lehmann, 1994)

nos coding region with sequences encoding the nos localization signal replaced by sequences encoding the putative localization signal from the bcd 3' UTR.

(Gavis and Lehmann, 1992)

Allele components

Component

Use(s)

Encoded product / tool

nanos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | dominant

(Wreden et al., 1997)

lethal | dominant | maternal effect

(Schulz and Tautz, 1995, Gavis and Lehmann, 1992)

Phenotype Manifest In

abdomen | ectopic

(Schulz and Tautz, 1994)

abdominal 1 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 2 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 3 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 4 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 5 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 6 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

abdominal 7 ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

embryo | anterior

(Simpson-Brose et al., 1994)

embryo | ectopic | posterior

(Simpson-Brose et al., 1994)

embryonic head | maternal effect

(Gavis and Lehmann, 1992)

embryonic thorax | anterior

(Simpson-Brose et al., 1994)

filzkorper | maternal effect

(Gavis and Lehmann, 1992)

mesothoracic ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

metathoracic ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

prothoracic ventral denticle belt | maternal effect

(Gavis and Lehmann, 1992)

Detailed Description

Statement

Reference

Embryos from females carrying one copy of the transgene form two posterior abdomens and termini in mirror image symmetry.

(Gavis and Lehmann, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

nanos^bcd.3UTR has abdomen | ectopic phenotype, suppressible by hb^bcd.3UTR

(Schulz and Tautz, 1994)

hb^Δ, nanos^bcd.3UTR has embryonic thorax | anterior phenotype, suppressible | maternal effect by bcd^Δ

(Simpson-Brose et al., 1994)

nanos^bcd.3UTR has embryo | posterior | ectopic phenotype, suppressible by bcd^Δ

(Simpson-Brose et al., 1994)

nanos^bcd.3UTR has embryo | anterior phenotype, suppressible by bcd^Δ

(Simpson-Brose et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Double abdomen phenotype of nos^bcd.3UTR is suppressed by hb^bcd.3UTR.

(Schulz and Tautz, 1994)

The bicaudal phenotype of embryos from nos^bcd.3UTR mothers is rescued by adding two maternal copies of bcd^Δ, resulting in restored polarity, correct head development and rescued abdominal denticle patterning. The embryos still lack the anterior thorax (due to lowered levels of hb activity).

(Simpson-Brose et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Ephrussi.

(Gavis and Lehmann, 1994)

E. Gavis and R. Lehmann.

(Jongens et al., 1994)

Comments

One insertion of this allele termed "n-b^var", with incomplete penetrance, demonstrates a correlation between the amount of localized nos RNA, the degree of hb (maternal) translation and the pattern of Kr, kni and gt transcription.

(Gavis and Lehmann, 1992)

Substantially overproduce nos protein.

(Murata and Wharton, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

NosA

(Simpson-Brose et al., 1994)

nanos^bcd.3UTR

nos^ant

(Wreden et al., 1997)

nos^bcd.3UTR

(Sano et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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