FB2024_03 , released June 25, 2024
Allele: Dmel\Su(Tpl)10
Open Close
General Information
Symbol
Dmel\Su(Tpl)10
Species
D. melanogaster
Name
FlyBase ID
FBal0034034
Feature type
allele
Associated gene
Dmel\Su(Tpl)
Associated Insertion(s)
Carried in Construct
Also Known As
Tpl10
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: W436term.

(Eissenberg et al., 2002)

possibly insertion of unidentified mobile element.

(Dorer and Christensen, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,893,397..19,893,397 [-]
Nucleotide change:

G19893397A

Amino acid change:

W436term | Su(Tpl)-PA; W436term | Su(Tpl)-PB; W436term | Su(Tpl)-PC

Reported amino acid change:

W436term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Eissenberg et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The hetero-allelic combination Su(Tpl)10/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: Mutant cuticles display the following defects, with variable penetrance: abdominal segment 2 missing, incomplete or fused to abdominal segment 3; abdominal segment 4 incomplete or fused to abdominal segment 3 or 5; metathoracic segment missing, incomplete or fused to abdominal segment 1; incomplete head involution.

      (Eissenberg et al., 2002)

      site-specific increase in recombination frequency and in premeiotic recombination in males.

      (Dorer and Christensen, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Su(Tpl)[+]/Su(Tpl)10 is an enhancer of wing margin phenotype of Nnd-1

      (Eissenberg et al., 2002)

      Su(Tpl)[+]/Su(Tpl)10 is an enhancer of wing margin phenotype of ct53d

      (Eissenberg et al., 2002)
      Suppressor of
      Statement
      Reference

      Su(Tpl)10 is a suppressor of phenotype of Tplunspecified

      (Dorer et al., 1995, Dorer et al., 1993)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Su(Tpl)10 entirely eliminates the abnormalities and death caused by Tpl trisomy (such as Dp(3;3)Tpl or Dp(3;3)TplJE19 flies), and results in viable, fertile adults.

      (Smoyer et al., 2003)

      Suppresses the triplo-lethal effect of Tpl.

      (Dorer et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      This mutation was previously reported to be an allele of Tpl (FBrf0051978). However, the effect on Tpl has been found not to map to the Tpl locus itself at 83E, but instead maps to a separate locus called Su(Tpl) at 76B-76D.

      (Dorer et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Su(Tpl)10
      (Christensen et al., 2008.4.15)
      Tpl10
      (Lindsley and Zimm, 1992, Dorer and Christensen, 1990, Homyk and Emerson, 1988)
      Tplrv3
      (Lindsley and Zimm, 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)