FB2024_03 , released June 25, 2024
Allele: Dmel\PTSal
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General Information
Symbol
Dmel\P\TSal
Species
D. melanogaster
Name
FlyBase ID
FBal0033950
Feature type
allele
Associated gene
P\T
Associated Insertion(s)
Carried in Construct
P{P-Sal}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Gloor et al., 1993, Lemaitre et al., 1993, Rasmusson et al., 1993, Banga et al., 1991, Ronsseray et al., 1991, Karess and Rubin, 1984)
Progenitor genotype
P\T+tPryB
(Karess and Rubin, 1984)
Carried in construct
P{P-Sal}
Cytology
Description

Insertion of 4bp at the SalI site within ORF3.

(Karess and Rubin, 1984)
Allele components
Component
Use(s)
Regulatory region(s)
P\T
Encoded product / tool
P\T
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The w marker in the P{lacW}ciDplac insertion does not normally variegate, producing flies with a uniform red eye phenotype in a w[-] background. However, in combination with P\TSal variegation due to P-element dependent silencing (PDS) is seen, resulting in flies with a variegated to strongly silenced, near-white eye colour.

      P\TSal also causes P-element dependent silencing of the w marker in the P{hsp26-pt-T}ci2-M1021.R insertion.

      Expression of the w marker in the P{hsp26-pt-T}39C-12 insertion line normally shows variegation, but this is suppressed by P\TSal, resulting in flies with a red eye phenotype in a w[-] background.

      (Sameny et al., 2011)

      P{P-Sal} fails to repress gonadal dysgenesis, either through a maternal effect or through a combination of zygotic and maternal effects, with or without heat shock.

      (Simmons et al., 1996)

      Repression of P-element mobility in somatic tissues, only weak repression of dysgenic sterility.

      (Lemaitre et al., 1993)

      Completely suppresses the vg21-3 mutant phenotype. Repressor of gonadal dysgenic sterility and snw mutability.

      (Rasmusson et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      P\TSal is a suppressor | partially of visible phenotype of Df(2R)vg-B/vg21

      (Anderson et al., 2006)

      P\TSal is a suppressor | partially of visible phenotype of Df(2R)vg-B/vg21-3

      (Anderson et al., 2006)

      P\TSal is a suppressor of visible phenotype of vg21-3

      (Anderson et al., 2006)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      P\TSal is a suppressor | partially of wing phenotype of Df(2R)vg-B/vg21

      (Anderson et al., 2006)

      P\TSal is a suppressor | partially of wing phenotype of Df(2R)vg-B/vg21-3

      (Anderson et al., 2006)

      P\TSal is a suppressor of wing phenotype of vg21-3

      (Anderson et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The presence of P\TSal partially suppresses the nicking of the wing that is seen in vg21/Df(2R)vg-B animals.

      The severe wing defects seen in vg21-3 homozygotes are completely suppressed by the presence of P\TSal.

      The severe wing defects seen in vg21-3/Df(2R)vg-B animals are almost completely suppressed by the presence of P\TSal.

      (Anderson et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Reverses the high chromosome instability caused by P\TΔ2-3 in mei-41D3 and mei-41RT1 mutant flies.

      (Banga et al., 1991)

      Does not produce any active transposase. Originally described by Karess and Rubin, Cell 38:135-146 .

      (Rasmusson et al., 1993)

      P{P-Sal} can repress P-element mobility in the soma and pupal lethality associated with Δ2-3 mobilization of nonautonomous P-elements in the soma. Mobilization of the putative repressor making element causes transposase induced loss of the suppressive effect on vg21-3 phenotype confirming that P-element are responsible for the suppressive effect.

      (Gloor et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      P\TSal
      Name Synonyms
      Secondary FlyBase IDs
        References (13)