FB2024_03 , released June 25, 2024
Allele: Dmel\vg21-3
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General Information
Symbol
Dmel\vg21-3
Species
D. melanogaster
Name
FlyBase ID
FBal0033088
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
P{}vg21-3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Gloor et al., 1993, Williams et al., 1988)
Progenitor genotype
vg21
(Williams et al., 1988)
Associated Insertion(s)
P{}vg21-3
Cytology
Description

Insertion of a P-element which has a deletion of bases 1862-2015 with a 2bp AT insertion at the deletion site. The inserted element also has a single A to T transversion at position 32.

(Anderson et al., 2006)

P element insertion.

(Rio, 1990)

Novel recruitment of additional P-element sequences.

(Williams et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and vg21-3/Df(2R)vg-B animals show severe defects in the wing.

      (Anderson et al., 2006)

      vg21-3/Df(2R)vg-B flies show a strong vestigial wing phenotype.

      (Bushey and Locke, 2004)

      Homozygotes: extreme wing phenotype. Heterozygotes with Df(2R)vg-B in M cytotype: extreme wing phenotype. Heterozygotes with Df(2R)vg-B in cytotype: wild type wing phenotype.

      (Hodgetts and O'Keefe, 2001)

      Extreme vg phenotype, fully vestigal wing, in a M cytotype that maybe partially or completely suppressed in a P cytotype. A single repressor making P-element can suppress the vg phenotype, increasing repressor strength causes gradual increase in wing material to wild type.

      (Gloor et al., 1993)

      Homozygotes have no wings.

      (Rabinow and Birchler, 1990)

      Exhibits a mutant phenotype in M cytotype, but is suppressed in a P cytotype.

      (Rio, 1990)

      Homozygotes display an extreme vg phenotype, heterozygotes with vg1 are completely suppressed when in the P-cytotype and the M-cytotype has no effect.

      (Williams et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Df(2R)vg-B/vg21-3 has visible phenotype, suppressible | partially by P\TSal

      (Anderson et al., 2006)

      vg21-3 has visible phenotype, suppressible by P\TSal

      (Anderson et al., 2006)

      Df(2R)vg-B/vg21-3 has visible phenotype, suppressible by P{P-Sal}Pak3P-Sal

      (Bushey and Locke, 2004)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(2R)vg-B/vg21-3 has wing phenotype, suppressible | partially by P\TSal

      (Anderson et al., 2006)

      vg21-3 has wing phenotype, suppressible by P\TSal

      (Anderson et al., 2006)

      Df(2R)vg-B/vg21-3 has wing phenotype, suppressible by P{P-Sal}Pak3P-Sal

      (Bushey and Locke, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severe wing defects seen in vg21-3 homozygotes are completely suppressed by the presence of P\TSal.

      The severe wing defects seen in vg21-3/Df(2R)vg-B animals are almost completely suppressed by the presence of P\TSal.

      (Anderson et al., 2006)

      The strong vestigial wing phenotype of vg21-3/Df(2R)vg-B animals is suppressed by P{P-Sal}89D. This suppression of the phenotype by P{P-Sal}89D is not affected by the presence of Su(var)3-7P9.

      (Bushey and Locke, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used as assay for P element suppression in study of properties of individually isolated, naturally occurring P elements.

      (Rasmusson et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vg21-3
      (Anderson et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)