FB2024_03 , released June 25, 2024
Allele: Dmel\NC1693S.hs
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General Information
Symbol
Dmel\NC1693S.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0033827
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{C1693>S}
Key Links
Transgenic product class
missense_variant
(Lieber et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lieber et al., 1993)
Mutagen
in vitro construct
(Lieber et al., 1993)
Progenitor genotype
Carried in construct
P{C1693>S}
Cytology
Description

Mutation of Cys1693.

(Lieber et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Males carrying NC1693S.hs reared at 25[o]C subjected to two 1 hour heat pulses per day, beginning 3 days post-eclosion, exhibit a significant decline in lifespan. Without the 37[o]C heat pulses, lifespan is unaffected.

      (Presente et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      NC1693S.hs is a suppressor of nervous system phenotype of bibunspecified

      (Lieber et al., 1993)
      NOT Suppressor of
      Statement
      Reference

      NC1693S.hs is a non-suppressor of nervous system phenotype of E(spl)m8-HLHunspecified

      (Lieber et al., 1993)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fails to rescue the neurogenic phenotype of E(spl) mutants but rescues the neurogenic phenotype of bib mutants.

      (Lieber et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      NC1693S.hs fails to rescue N264-47

      (Lieber et al., 1993)
      Comments

      Neural hypoplasia. Strong antineurogenic phenotype that is independent of the N background. Unable to rescue the cuticle phenotype of N264-47 embryos.

      (Lieber et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Incomplete N protein.

      (Lieber et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      C1693>S
      (Lieber et al., 1993)
      NC1693S.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (2)