FB2024_03 , released June 25, 2024
Allele: Dmel\Fas1+t23
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General Information
Symbol
Dmel\Fas1+t23
Species
D. melanogaster
Name
FlyBase ID
FBal0033678
Feature type
allele
Associated gene
Dmel\Fas1
Associated Insertion(s)
Carried in Construct
P{fas1+}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Elkins et al., 1990)
wild_type
(Elkins et al., 1990)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Elkins et al., 1990)
wild_type
(Elkins et al., 1990)
Mutagen
in vitro construct
(Zhong and Shanley, 1995, Elkins et al., 1990)
Progenitor genotype
Carried in construct
P{fas1+}
Cytology
Description

Contained within a 23kb genomic KpnI fragment.

(Elkins et al., 1990)
Allele components
Component
Use(s)
Regulatory region(s)
Fas1
Encoded product / tool
Fas1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:16,622,066..16,644,165 [+]
Linked to:
KpnI-KpnI restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Elkins et al., 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nerve terminal arborisation onto muscles is reduced compared to wild-type in flies carrying Fas1+t23. Type 2 and type 1 terminals are affected. The excitatory junctional currents of muscle fibre 12 are increased in amplitude compared to wild-type.

      (Zhong and Shanley, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rescues the CNS axonal defect phenotype of Fas1, Abl double mutants.

      (Elkins et al., 1990)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Fas1+t23 rescues Fas1TE89Da

      (Zhong and Shanley, 1995)
      Comments

      Rescues the CNS axonal defect phenotype of Fas1, Abl double mutants.

      (Elkins et al., 1990)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fas1+t23
      Name Synonyms
      Secondary FlyBase IDs
        References (2)