FB2024_03 , released June 25, 2024
Allele: Dmel\Fas1TE89Da
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General Information
Symbol
Dmel\Fas1TE89Da
Species
D. melanogaster
Name
FlyBase ID
FBal0028191
Feature type
allele
Associated gene
Dmel\Fas1
Associated Insertion(s)
Carried in Construct
Also Known As
Fas1TE
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Hortsch and Goodman, 1993)

    loss of function allele

    (Zhong and Shanley, 1995)
    Mutagen
    Progenitor genotype
    Caused by aberration
    Tp(1;3)TE89Da
    Cytology
    Description

    100kb insertion into the large intron of Fas1.

    (Hortsch and Goodman, 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Nerve terminal arborisation onto muscles is enhanced compared to wild-type. Type 2 but not type 1 terminals are affected. The excitatory junctional currents (ejcs) of muscle fibre 12 are decreased in amplitude compared to wild-type. The distribution of spontaneous miniature ejcs is altered compared to wild-type. Fas1TE89Da larvae carrying Fas1+t23 have a similar number of nerve terminal branches and varicosities to wild-type. ejcs have a normal amplitude.

        (Zhong and Shanley, 1995)

        Homozygotes are viable and fertile, no gross defects in the embryonic CNS. Abl1, Fas1TE89Da and Abl2, Fas1TE89Da double mutant embryos exhibit gross defects in the developing CNS axon guidance and the morphogenesis of CNS axon tracts: an allele specific interaction.

        (Elkins et al., 1990)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Fas1TE89Da is an enhancer of visible | recessive phenotype of bifunspecified

        (Bahri et al., 1997)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Fas1TE89Da is an enhancer of eye phenotype of bifunspecified

        (Bahri et al., 1997)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Enhances the bifunspecified rough eye phenotype.

        (Bahri et al., 1997)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Fas1TE89Da is rescued by Fas1+t23

        (Zhong and Shanley, 1995)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        X ray generated w revertants have wild type levels of Fas1 protein in the embryo.

        (Hortsch and Goodman, 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Fas1TE89Da
        Fas1TE
        (Therianos et al., 1995, Zhong and Shanley, 1995, Elkins et al., 1990)
        TE77
        (Hortsch and Goodman, 1993)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)