FB2024_03 , released June 25, 2024
Allele: Dmel\tub3
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General Information
Symbol
Dmel\tub3
Species
D. melanogaster
Name
FlyBase ID
FBal0032950
Feature type
allele
Associated gene
Dmel\tub
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hecht and Anderson, 1993)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T386A. Amino acid replacement: V129D.

(Letsou et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:4,388,315..4,388,315 [+]
Nucleotide change:

T4388315A

Reported nucleotide change:

T386A

Amino acid change:

V129D | tub-PC

Reported amino acid change:

V129D

(Letsou et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Level of Drs induction of bacterially challenged tub3/tub1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of tub2/tub3 mutants with A.fumigatus causes 3% survival 3 days postinfection, infection with E.coli causes 71% survival 3 days postinfection.

      (Lemaitre et al., 1996)

      Strongly dorsalised embryos.

      (Hecht and Anderson, 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD1 are strongly dorsalizing.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3R)XM3/tub3 is rescued by tubptub462

      (Letsou et al., 1993)
      Partially rescued by

      Df(3R)XM3/tub3 is partially rescued by tubptubΔC205

      (Letsou et al., 1993)
      Not rescued by

      Df(3R)XM3/tub3 is not rescued by tubptubΔN256

      (Letsou et al., 1993)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Same mutation was introduced into a cDNA and used in RNA injection experiments, proving that the lesion is responsible for the tub maternal effect phenotype.

      (Letsou et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tub3
      (Tauszig-Delamasure et al., 2002)
      tube3
      (Shields et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)