FlyBase Allele Report: Dmel\ro[DOM]

General Information

Symbol

Dmel\ro^DOM

Species

D. melanogaster

Name

FlyBase ID

FBal0032584

Feature type

allele

Associated gene

Dmel\ro

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

gain of function allele

(Chanut et al., 2000)

Mutagen

X ray

(Chanut et al., 2000, Heberlein et al., 1993)

Progenitor genotype

Caused by aberration

T(2;3)ro^DOM

Cytology

Description

Rearrangement breaks 5' to the ro gene though the coding region of ro appears to be intact.

(Chanut et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Treisman et al., 1997)

visible | dominant

(Chanut et al., 2002, Chanut et al., 2000)

Phenotype Manifest In

eye

(Chanut et al., 2002, Chanut et al., 2000, Treisman et al., 1997, Heberlein et al., 1993)

eye disc morphogenetic furrow

(Chanut et al., 2000)

ommatidium

(Chanut et al., 2000)

Detailed Description

Statement

Reference

Ommatidial clusters in ro^DOM/+ eye discs and adult eyes exhibit severe over-rotation.

(Chou and Chien, 2002)

Stop-furrow phenotype. Eye size reduced and kidney shaped due to premature arrest of morphogenetic furrow progression. Ommatidial number reduced to fewer than 100.

(Chanut et al., 2000)

Arrests movement of the morphogenetic furrow in the eye resulting in a reduced adult eye that specifically lacks the anterior portion of the retina. Eye discs of third instar larvae display a 'furrow-stop' phenotype.

(Treisman et al., 1997)

Reduced eye. The progression of the morphogenetic furrow in the developing eye disc arrests. The eye disc appears normal at the time of arrest. dpp expression is abolished (as assayed with a dpp-lacZ fusion gene).

(Heberlein et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ro^DOM has visible phenotype, enhanceable by Delta¹³³³/Dl[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro^DOM)1065¹⁴⁸³/E(ro[DOM])1065[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro^DOM)1777¹⁷⁷⁷/E(ro[DOM])1777[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])1777[+]/E(ro^DOM)1777²⁵⁸⁶

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])1801[+]/E(ro^DOM)1801¹⁸⁰¹

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])1801[+]/E(ro^DOM)1801²⁷⁹⁶

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])2051[+]/E(ro^DOM)2051²⁰⁵¹

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])2051[+]/E(ro^DOM)2051²³⁷⁶

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])2409[+]/E(ro^DOM)2409²⁴⁰⁹

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro^DOM)3222³²²²/E(ro[DOM])3222[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])50[+]/E(ro^DOM)50¹⁷⁶⁶

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by Delta¹⁶⁵⁰/Dl[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro^DOM)50⁵⁰/E(ro[DOM])50[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by ato¹/ato[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by gl[+]/gl¹⁷⁹

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by Scer\GAL4^GMR.PF/hh^UAS.cCa

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by ptc^S2/ptc[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by Delta²⁸²¹/Dl[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by Delta⁵¹/Dl[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, enhanceable by E(ro[DOM])1065[+]/E(ro^DOM)1065¹⁰⁶⁵

(Chanut et al., 2000)

Suppressed by

Statement

Reference

ro^DOM has visible | dominant phenotype, suppressible by amos[+]/amos^Roi-Rev

(Chanut et al., 2002)

ro^DOM has visible | dominant phenotype, suppressible by amos^Roi-1/amos[+]

(Chanut et al., 2002)

ro^DOM has visible phenotype, suppressible by H[+]/H¹¹⁷¹

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])3023[+]/Su(ro^DOM)3023³⁰²³

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro^DOM)3023⁸⁷⁷/Su(ro[DOM])3023[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro^DOM)345³⁴⁵/Su(ro[DOM])345[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro^DOM)345⁶¹⁷/Su(ro[DOM])345[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])519[+]/Su(ro^DOM)519⁵¹⁹

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])923[+]/Su(ro^DOM)923¹²⁷⁵

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])923[+]/Su(ro^DOM)923⁹²³

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by ato^UAS.cJa/Scer\GAL4^h-H10

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro¹⁰⁵²/gro[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro¹³¹/gro[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by H¹⁹⁹⁷/H[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro[+]/gro²⁰⁵³

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro³⁴⁷/gro[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro⁷⁸¹/gro[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by gro⁹⁴²/gro[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by hh[+]/hh¹⁵⁸²

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by hh[+]/hh⁸

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa¹⁹⁴⁶/osa[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa[+]/osa²⁰⁵²

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa²⁴³⁸/osa[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa²⁷⁹¹/osa[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by H²⁹⁹/H[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa[+]/osa³⁰⁸

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by osa[+]/osa⁶¹⁶

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by ptc^EP941/Scer\GAL4^h-H10

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by hh[+]/hh⁷³⁷

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by H³¹⁹⁴/H[+]

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])1480[+]/Su(ro^DOM)1480¹⁴⁸⁰

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])1480[+]/Su(ro^DOM)1480²¹⁰⁴

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])1993[+]/Su(ro^DOM)1993¹⁹⁹³

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])1993[+]/Su(ro^DOM)1993²⁰⁸⁸

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by Su(ro[DOM])2014[+]/Su(ro^DOM)2014²⁰¹⁴

(Chanut et al., 2000)

ro^DOM has visible phenotype, suppressible by amos^Roi-1/amos[+]

(Heberlein et al., 1993)

Phenotype Manifest In

Enhanced by

Statement

Reference

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])1065[+]/E(ro^DOM)1065¹⁰⁶⁵

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro^DOM)1065¹⁴⁸³/E(ro[DOM])1065[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro^DOM)1777¹⁷⁷⁷/E(ro[DOM])1777[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])1777[+]/E(ro^DOM)1777²⁵⁸⁶

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])1801[+]/E(ro^DOM)1801¹⁸⁰¹

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by Delta¹³³³/Dl[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])1801[+]/E(ro^DOM)1801²⁷⁹⁶

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])2051[+]/E(ro^DOM)2051²⁰⁵¹

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])2051[+]/E(ro^DOM)2051²³⁷⁶

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])2409[+]/E(ro^DOM)2409²⁴⁰⁹

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro^DOM)3222³²²²/E(ro[DOM])3222[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro[DOM])50[+]/E(ro^DOM)50¹⁷⁶⁶

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by E(ro^DOM)50⁵⁰/E(ro[DOM])50[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by ato¹/ato[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by gl[+]/gl¹⁷⁹

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/hh^UAS.cCa

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by Delta¹⁶⁵⁰/Dl[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by ptc^S2/ptc[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by Delta²⁸²¹/Dl[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, enhanceable by Delta⁵¹/Dl[+]

(Chanut et al., 2000)

ro^DOM has phenotype, enhanceable by wg^l-17

(Treisman et al., 1997)

Suppressed by

Statement

Reference

ro^DOM has eye phenotype, suppressible by amos^Roi-1/amos[+]

(Chanut et al., 2002, Heberlein et al., 1993)

ro^DOM has eye phenotype, suppressible by amos[+]/amos^Roi-Rev

(Chanut et al., 2002)

ro^DOM has eye phenotype, suppressible by H[+]/H¹¹⁷¹

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by H¹⁹⁹⁷/H[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by H²⁹⁹/H[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by H³¹⁹⁴/H[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])1480[+]/Su(ro^DOM)1480¹⁴⁸⁰

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])1480[+]/Su(ro^DOM)1480²¹⁰⁴

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])1993[+]/Su(ro^DOM)1993¹⁹⁹³

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])1993[+]/Su(ro^DOM)1993²⁰⁸⁸

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])2014[+]/Su(ro^DOM)2014²⁰¹⁴

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])3023[+]/Su(ro^DOM)3023³⁰²³

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro^DOM)3023⁸⁷⁷/Su(ro[DOM])3023[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro^DOM)345³⁴⁵/Su(ro[DOM])345[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro^DOM)345⁶¹⁷/Su(ro[DOM])345[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])519[+]/Su(ro^DOM)519⁵¹⁹

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])923[+]/Su(ro^DOM)923¹²⁷⁵

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by Su(ro[DOM])923[+]/Su(ro^DOM)923⁹²³

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by ato^UAS.cJa/Scer\GAL4^h-H10

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro¹⁰⁵²/gro[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro¹³¹/gro[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro[+]/gro²⁰⁵³

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro³⁴⁷/gro[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro⁷⁸¹/gro[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by gro⁹⁴²/gro[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by hh[+]/hh¹⁵⁸²

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by hh[+]/hh⁷³⁷

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by hh[+]/hh⁸

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa¹⁹⁴⁶/osa[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa[+]/osa²⁰⁵²

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa²⁴³⁸/osa[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa²⁷⁹¹/osa[+]

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa[+]/osa³⁰⁸

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa[+]/osa⁶¹⁶

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by ptc^EP941/Scer\GAL4^h-H10

(Chanut et al., 2000)

ro^DOM has eye phenotype, suppressible by osa³⁰⁸

(Treisman et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

amos^Roi-Rev/+ has some ability to suppress the furrow-stop eye phenotype of ro^DOM.

(Chanut et al., 2002)

osa³⁰⁸ mutation suppresses the ro^DOM phenotype, not by allowing further progression of the furrow but by reinitiation of photoreceptor differentiation at the dorsal and ventral edges of the eye disc. Reduction of wg function reduces the eye size and the extent of photoreceptor differentiation along the disc margins.

(Treisman et al., 1997)

Reduced eye phenotype is suppressed by amos^Roi-1.

(Heberlein et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

EMS-induced revertants of ro^DOM fail to complement loss of function alleles of ro.

(Chanut et al., 2000)

Associated with a T(2;3) translocation that is not further described.

(Heberlein et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ro^D

(Majot and Bidwai, 2017)

ro^DOM

ro^Dom

(Chanut et al., 2002, Chanut et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close