FlyBase Allele Report: Dmel\px[72]

General Information

Symbol

Dmel\px⁷²

Species

D. melanogaster

Name

FlyBase ID

FBal0032530

Feature type

allele

Associated gene

Dmel\px

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Matakatsu et al., 1999)

loss of function allele

(Milan et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q339term.

(Matakatsu et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:22,555,769..22,555,769 [-]

Nucleotide change:

C22555769T

Amino acid change:

Q339term | px-PA; Q339term | px-PE; Q339term | px-PF; Q339term | px-PG

Reported amino acid change:

Q339term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Matakatsu et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Matakatsu et al., 1999, Milan et al., 1997, Wessendorf et al., 1992)

visible | recessive | somatic clone

(Baonza and Garcia-Bellido, 1999, Milan et al., 1997)

Phenotype Manifest In

wing

(Matakatsu et al., 1999, Wessendorf et al., 1992)

wing vein

(Milan et al., 1997)

wing vein | ectopic

(Matakatsu et al., 1999)

wing vein | ectopic | somatic clone

(Baonza and Garcia-Bellido, 1999, Milan et al., 1997)

Detailed Description

Statement

Reference

Homozygotes have extra wing veins.

(Baonza and Garcia-Bellido, 1999)

Excess wing veins appear between L1 and L3, and posterior to L4. The L3-L4 territory is usually clear of veins except for an ectopic longitudinal vein reaching directly inwards from the wing margin. The L3-L4 territory is wider than in wild type, due to an increase in cell number. The phenotype is more pronounced when px⁷² is heterozygous with Df(2R)X58-5. Shows no defect outside the wing when homozygous.

(Matakatsu et al., 1999)

Homozygotes have plexates mostly in the distal vein stretches of the wing, connecting and approaching LII and LIII on the one hand and LV on the other. Dorsal and ventral implants of px⁷² imaginal disc tissue into wild-type imaginal discs produce plexates between LII and LIII, and LIV and LV. Homozygous clones in the wing differentiate extra vein tissue between LII and LIII and between LIV and LV. Clones located in both surfaces of the wing have a stronger phenotype than those located on only one surface.

(Milan et al., 1997)

Appearance of distal extra longitudinal veins preferentially associated with plexi between LII and LIII on one side and between LIV and LV on the other.

(Diaz-Benjumea and Garcia-Bellido, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

px⁷² has visible | recessive phenotype, enhanceable by emc¹/emc[+]

(Baonza and Garcia-Bellido, 1999)

px⁷² has visible | recessive phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Suppressed by

Statement

Reference

px⁷² has visible | recessive phenotype, suppressible by emc^D

(Baonza and Garcia-Bellido, 1999)

px⁷² has visible | recessive phenotype, suppressible by rho^ve-1/rho^ve-1

(Wessendorf et al., 1992)

Other

Statement

Reference

bs⁰³²⁶⁷, px⁷² has visible phenotype

(Matakatsu et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

px⁷² has wing vein | ectopic phenotype, enhanceable by emc¹/emc[+]

(Baonza and Garcia-Bellido, 1999)

px⁷² has wing vein | ectopic phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

px⁷² has phenotype, enhanceable by bs⁰³²⁶⁷

(Roch et al., 1998)

Suppressed by

Statement

Reference

net¹, px⁷² has wing vein | ectopic phenotype, suppressible by osa[+]/brm[+]/osa³⁰⁸/brm²

(Terriente-Félix and de Celis, 2009)

px⁷² has wing vein | ectopic phenotype, suppressible by emc^D

(Baonza and Garcia-Bellido, 1999)

px⁷² has wing phenotype, suppressible by rho^ve-1/rho^ve-1

(Wessendorf et al., 1992)

Enhancer of

Statement

Reference

px[+]/px⁷² is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Other

Statement

Reference

net¹, px⁷² has wing vein | ectopic phenotype

(Terriente-Félix and de Celis, 2009)

emc¹/emc¹¹, px⁷² has wing vein phenotype

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷, px⁷² has wing phenotype

(Matakatsu et al., 1999)

bs⁰³²⁶⁷, px⁷² has wing vein | ectopic phenotype

(Matakatsu et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

net¹, px⁷² double mutants develop ectopic wing veins in the L2/L3 and L4/L5 intervein regions. This phenotype is suppressed in flies double heterozygous for osa³⁰⁸ and brm².

(Terriente-Félix and de Celis, 2009)

The extra wing vein phenotype of px⁷² homozygotes is suppressed by emc^D and enhanced by emc¹/+ or emc¹/emc¹¹. The ectopic wing vein phenotype of px⁷² wings is exaggerated in regions occupied by emc¹ homozygous clones. The borders of the emc¹ clones respect not only normal veins as restriction borders, but also tend not to cross ectopic veins.

(Baonza and Garcia-Bellido, 1999)

Transheterozygotes of px⁷² with bs⁰³²⁶⁷ show ectopic venation.

(Matakatsu et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

px⁷² is rescued by px^hs.PM

(Matakatsu et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

px⁷²

(Terriente-Félix and de Celis, 2009)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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