FlyBase Allele Report: Dmel\otu[PΔ3]

General Information

Symbol

Dmel\otu^PΔ3

Species

D. melanogaster

Name

FlyBase ID

FBal0032354

Feature type

allele

Associated gene

Dmel\otu

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Rodesch et al., 1997)

Mutagen

P-element activity

(Steinhauer and Kalfayan, 1992)

PM hybrid dysgenesis

(Geyer et al., 1993, Sass et al., 1993)

Progenitor genotype

otu²⁰

(Geyer et al., 1993, Sass et al., 1993)

Cytology

Description

Deletion in the promoter region.

(Bae et al., 1994)

450 bp upstream of the cDNA start site deleted.

(Bopp et al., 1993)

Deletion of 437bp of 5' flanking region starting at one end of (and including most of) the P element, leaving intact the major transcription start sites of otu.

(Geyer et al., 1993)

437bp deletion with the same downstream endpoint as otu^PΔ6 : both retain the same 14bp sequence of the inverted repeat. Upstream boundary of the deletion is at -446, thus the deletion is less extensive than that of otu^PΔ6, though both remove all known otu regulatory regions.

(Sass et al., 1993)

Deletion of approximately 450bp, upstream of the cDNA start site, leaving the coding region unaltered.

(Steinhauer and Kalfayan, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:8,489,509..8,489,946 [-]

Comment:

437 bp deletion of 5' flanking region associated with the imprecise excision of P{}otu²⁰.

(Geyer et al., 1993, Sass et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Bae et al., 1994)

female sterile | recessive

(Bopp et al., 1993, Geyer et al., 1993, Sass et al., 1993)

neoplasia | female

(Hinson and Nagoshi, 2002)

Phenotype Manifest In

fusome

(Rodesch et al., 1997)

germline cell

(Nagoshi et al., 1995)

nurse cell ring canal

(Rodesch et al., 1997)

ovary

(Bae et al., 1994, Bopp et al., 1993, Geyer et al., 1993, Steinhauer and Kalfayan, 1992)

Detailed Description

Statement

Reference

The ring canals are devoid of fusome material and have inner rims that are indistinguishable from wild-type in homozygous females. Ring canals lacking both fusomes and an inner ring are also seen in these females and a number of ring canals that are a fraction of wild-type size are occasionally seen. Fusomes contain actin filaments.

(Rodesch et al., 1997)

Tumorous phenotype.

(Rodesch et al., 1995, Bopp et al., 1993)

When XY flies are transformed into pseudofemales by tra^Hsp83.PS, otu^PΔ3/Y flies produce primarily agametic pseudoovaries at frequencies similar to that obtained with otu¹⁰ and Df(1)otu-PΔ1.

(Nagoshi et al., 1995)

Tumorous ovaries.

(Bae et al., 1994)

Few quiescent ovaries though majority show tumorigenic phenotype with occasional mature cysts.

(Geyer et al., 1993)

Homozygous females have tumorous ovaries, hemizygous females have quiescent ovaries.

(Steinhauer and Kalfayan, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

otu^PΔ3 is partially rescued by otu^hs.PN

(Rodesch et al., 1995)

Comments

One or two copies of otu^hs.PN causes substantial morphological suppression but only partial suppression of sterility.

(Rodesch et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Oncogenic class (ONC) of otu allele.

(Steinhauer and Kalfayan, 1992)

ONC class allele. Phenotype less severe than otu^PΔ6.

(Sass et al., 1993)

TUM class allele.

(Geyer et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

otu^PΔ3

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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