FlyBase Allele Report: Dmel\Orc3[vr6.35]

General Information

Symbol

Dmel\Orc3^vr6.35

Species

D. melanogaster

Name

FlyBase ID

FBal0032080

Feature type

allele

Associated gene

Dmel\Orc3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Boynton and Tully, 1992)

Progenitor genotype

Orc3^P1

(Boynton and Tully, 1992)

Cytology

Description

200 bp deletion in exon 6 (nucleotides 1271-1470).

(Pinto et al., 1999)

Generated by excision of P{w^d19.3} in lat^P1.

(Boynton and Tully, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:13,204,899..13,205,098 [-]

Comment:

200 bp deletion

(Pinto et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory

(Boynton and Tully, 1992)

abnormal size | third instar larval stage (with Orc3^lE344)

(Pinto et al., 1999)

decreased occurrence of cell division | third instar larval stage

(Pinto et al., 1999)

lethal

(Boynton and Tully, 1992)

lethal - all die before end of pupal stage | recessive

(Pinto et al., 1999)

some die during pupal stage | recessive

(Pinto et al., 1999)

Phenotype Manifest In

embryonic/larval central nervous system

(Pinto et al., 1999)

imaginal disc

(Pinto et al., 1999)

Detailed Description

Statement

Reference

Mutants die at pupal stage P3. Third instar lat^vr6.35/lat^lE344 larvae lack imaginal discs and show an undersized CNS, although the gross morphology of imaginal discs and CNS in second instar larvae appears normal. No BrdU incorporation is seen in third instar brains, reflecting lack of cell proliferation, whereas 2nd instar brains appear normal.

(Pinto et al., 1999)

Decrement in 15-minute memory retention.

(Boynton and Tully, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Orc3^vr6.6

(Pinto et al., 1999)

Orc3^lE49

(Pinto et al., 1999)

Orc3^lE344

(Pinto et al., 1999)

Rescued by

Orc3^vr6.35 is rescued by Orc3^+t17.1

(Pinto et al., 1999)

Comments

Complementation statement based on recessive pupal lethality phenotype.

(Pinto et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Orc3^vr6.35

lat^vr6.35

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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