FB2024_03 , released June 25, 2024
Allele: Dmel\Tm2J8
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General Information
Symbol
Dmel\Tm2J8
Species
D. melanogaster
Name
FlyBase ID
FBal0032025
Feature type
allele
Associated gene
Dmel\Tm2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kreuz et al., 1996)
Progenitor genotype
Cytology
Description

Mutation within the second exon.

(Kreuz et al., 1996)

Amino acid replacement: Q28term.

(Kreuz et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,312,534..15,312,534 [+]
Nucleotide change:

C15312534T

Amino acid change:

Q28term | Tm2-PA; Q28term | Tm2-PB; Q28term | Tm2-PC; Q28term | Tm2-PE; Q28term | Tm2-PF; Q28term | Tm2-PG

Reported amino acid change:

Q28term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kreuz et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Tm2J8 is a non-suppressor of lethal | male phenotype of flw6

      (Vereshchagina et al., 2004)

      Tm2[+]/Tm2J8 is a non-suppressor of visible phenotype of wupAhdp-2

      (Naimi et al., 2001)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Tm2[+]/Tm2J8 is a suppressor of indirect flight muscle cell phenotype of wupAhdp-2

      (Naimi et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      Tm2[+]/Tm2J8 is a non-suppressor of wing phenotype of wupAhdp-2

      (Naimi et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The upheld wing phenotype of wupAhdp-2 flies is not suppressed by Tm2J8/+. The IFM hypercontraction phenotype seen in wupAhdp-2 flies is partially suppressed by Tm2J8/+.

      (Naimi et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Tm2J8 is rescued by Tm2+tΔ-2500

      (Kreuz et al., 1996)
      Comments

      The flightless behaviour and recessive lethality caused by Tm2J8 are completely rescued by Tm2+tΔ-2500.

      (Kreuz et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      J8
      (Naimi et al., 2001, Vigoreaux, 2001)
      Tm2J8
      Tm2nc99Eb-J8
      l(3)nc99EbJ8
      Name Synonyms
      Secondary FlyBase IDs
        References (6)