FlyBase Allele Report: Dmel\dlg1[sw]

General Information

Symbol

Dmel\dlg1^sw

Species

D. melanogaster

Name

FlyBase ID

FBal0031043

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^sw

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

100bp deletion starting at 2840bp expected to cause a truncation of the C-terminus to the GUK domain.

(Woods et al., 1996)

100bp deletion changes carboxy end of the protein.

(Woods and Bryant, 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,406,135..11,406,234 [+]

Comment:

100bp deletion changes carboxy-terminal end of the protein.

(Woods and Bryant, 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect

(Woods et al., 1996)

some die during embryonic stage | maternal effect

(Woods et al., 1996)

viable

(Goode and Perrimon, 1997, Woods et al., 1996)

visible

(Woods et al., 1996)

Phenotype Manifest In

embryonic epidermis | dorsal | maternal effect

(Woods et al., 1996)

external sensory organ precursor cell I

(Bellaiche et al., 2001)

follicle cell

(Goode and Perrimon, 1997)

interommatidial bristle

(Woods et al., 1996)

Detailed Description

Statement

Reference

dlg1^sw mutant larvae do not display neuroblast overproliferation.

(Mauri et al., 2014)

In mutant pI cells the onset of spindle rotation is delayed. Unlike the wild-type, rotation is observed in late metaphase.

(Bellaiche et al., 2001)

Follicle cells do not have an invasive phenotype in homozygous females, although follicle cells appear to overaccumulate at the anterior and posterior poles of the egg chambers. Border cells migrate in advance of the follicular epithelium in dlg1^sw/dlg1² egg chambers.

(Goode and Perrimon, 1997)

Adults exhibit minor bristles defects including missing and duplicated bristles. Embryos produced from homozygous females fail to hatch and die during late embryogenesis with a failure of dorsal closure and terminal defects.

(Woods et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dlg1^sw, wake^Δ has neoplasia phenotype

(Mauri et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

dlg1^sw, wake^Δ has embryonic/larval brain phenotype

(Mauri et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

In contrast to either allele alone, the brains of dlg1^sw, wake^Δ double mutant larvae contain massive tumors.

(Mauri et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Class II mutation.

(Woods et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dlg1^sw

dlg^SW

(Bellaiche et al., 2001)

dlg^sw

(Mauri et al., 2014, Bellaiche et al., 2001, Goode and Perrimon, 1997, Woods et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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