FB2024_03 , released June 25, 2024
Allele: Dmel\btdXA
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General Information
Symbol
Dmel\btdXA
Species
D. melanogaster
Name
FlyBase ID
FBal0030657
Feature type
allele
Associated gene
Dmel\btd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Vincent et al., 1997, Wimmer et al., 1993)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Construct: Amino acid replacement: Q70@.

    (Wimmer et al., 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:9,694,881..9,694,881 [+]
    Nucleotide change:

    C9694881T

    Amino acid change:

    Q70term | btd-PA

    Reported amino acid change:

    Q70term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Wimmer et al., 1993)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Type II neuroblasts in homozygous clones in the larval brain maintain a type II neuroblast marker expression profile. They appear to generate non-functional ase[-] immature intermediate neural progenitors that likely adopt an identity of ganglion mother cells normally found in the type I neuroblast lineage.

        (Komori et al., 2014)

        Homozygous embryos fail to form a cephalic furrow. The ventral furrow and proctodeal invagination form normally. No signs of initiator cell activity are seen between the beginning of cycle 14 and stage 7.

        (Vincent et al., 1997)

        The lateral pentascolopidial chordotonal organs (lch5) in the abdominal segments contain an average of 3 to 4 scolopidia in mutant embryos.

        (Wimmer et al., 1996)

        A weak allele of btd. Mandibular, intercalary and antennal segments absent.

        (Cohen and Jurgens, 1990)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Phenotype Manifest In
        Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        btdXA ; bratunspecified double mutant clones in the larval brain do not lead to supernumerary neuroblast formation.

        (Komori et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        btdXA is rescued by btdRV-2ndB

        (Wimmer et al., 1997)

        btdXA is rescued by btdhb.PW

        (Wimmer et al., 1997)
        Partially rescued by

        btdXA is partially rescued by btd+t10.5

        (Wimmer et al., 1996)
        Not rescued by

        btdXA is not rescued by btdFRT.hb

        (Wimmer et al., 1997)

        btdXA is not rescued by btdFRT.RV-2ndB

        (Wimmer et al., 1997)
        Comments

        The reduction in the number of scolopidia in lch5 in btdXG embryos is partially rescued by btd+t10.5.

        (Wimmer et al., 1996)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        XA17
        (Wimmer et al., 1993)
        btdAX
        (Eritano et al., 2020)
        btdXA
        (Newcomb et al., 2018, Komori et al., 2014, Spahn et al., 2014, Estella and Mann, 2010, Popodi et al., 2010-)
        Name Synonyms
        Secondary FlyBase IDs
          References (14)