FB2024_03 , released June 25, 2024
Allele: Dmel\NM1
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General Information
Symbol
Dmel\NM1
Species
D. melanogaster
Name
FlyBase ID
FBal0029949
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Couso and Martinez Arias, 1994, de Celis et al., 1993, de Celis et al., 1991)

loss of function allele

(de Celis et al., 1993)
Mutagen
ethyl methanesulfonate
(de Celis et al., 1993, de Celis et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: E412V.

(Couso and Martinez Arias, 1994)

Mutation falls in EGF repeat number 12 and affects the Dl binding domain.

(Couso and Martinez Arias, 1994)

Amino acid replacement: E491V. The E491V substitution falls within EGF repeat 12. Only EGF repeats 11 and 12 were examined for mutant lesions.

(de Celis et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:3,164,100..3,164,100 [+]
Nucleotide change:

A3164100T

Reported nucleotide change:

A?T

Amino acid change:

E491V | N-PA; E491V | N-PB

Reported amino acid change:

E491V

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(de Celis et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous lethal. Heterozygotes have a neurogenic phenotype and have an increase in the number of thoracic bristles compared to wild-type. The number of bristles is restored almost to wild-type in NM1 ; Dp(1;2)51b double heterozygotes.

      (Brennan et al., 1997)

      NM1 defines a new class of Notch allele. Hemizygous embryos die with severe neurogenic phenotype. Shows classic Notch phenotype when transheterozygous with fa and nd classes of alleles. Antimorphism revealed in males where the lethality is rescued by a duplication for Notch but the rescued males retain a wing vein thickening and notched wing phenotype. NM1 shows suppressive interactions with "NAx" alleles of both the enhancer of Notch and suppressor of Notch class, but lethal Abruptex class Notch alleles are lethal when heterozygous with NM1. Suppressive interactions also evident with alleles of the split class of Notch alleles.

      (de Celis et al., 1993)

      Lack of chaetae.

      (de Celis et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      NM1 has visible | dominant phenotype, suppressible by wgS107

      (Brennan et al., 1997)
      Other
      Statement
      Reference

      Df(3R)Delta-FX3, NM1 has lethal | dominant phenotype

      (Brennan et al., 1997)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      NM1 has adult thoracic sensillum phenotype, suppressible by wgS107

      (Brennan et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The number of bristles is restored to wild-type in NM1 ; wgS107 double heterozygotes. NM1 ; Df(3R)Dl-FX3 double heterozygotes die before pupation.

      (Brennan et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      NAx-59d

      (Brennan et al., 1997)
      Fails to complement

      Nspl-1

      (Brennan et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Genetic interactions with Delta and Serrate alleles of the Beaded locus suggest that NM1 products have modified binding abilities with both Dl and Bd products. Similarity with and lack of specificity of interaction of N- and NM1 with H, mam, gro and E(spl) suggest that the NM1 effect is due to modification in the intracellular signalling of the activated N receptor.

      (de Celis et al., 1993)

      Shows little or no allele-specific interaction with wgl-12, and no allele-specific interaction with wgl-15, wgS107 or wgS84.

      (Couso and Martinez Arias, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NM1
      Name Synonyms
      Secondary FlyBase IDs
        References (7)