FB2024_03 , released June 25, 2024
Allele: Dmel\Khc5
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General Information
Symbol
Dmel\Khc5
Species
D. melanogaster
Name
FlyBase ID
FBal0029877
Feature type
allele
Associated gene
Dmel\Khc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gho et al., 1992)
Mutagen
ethyl methanesulfonate
(Saxton et al., 1991)
Progenitor genotype
Cytology
Description

Point mutation.

(Saxton et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Khc4/Khc5 heteroallelic flies cultured at 22oC become paralysed at 39oC. The temperature threshold for this behavior is higher than that for mlenap-ts1 or parats1, and the timecourse of recovery is slower. For many minutes the flies remain sluggish. Shows no bang sensitivity.

      (Hurd et al., 1996)

      Impairs action potential propagation in axons and neurotransmitter release at nerve terminals, but has no effect on the concentration of synaptic vesicles in nerve terminal cytoplasm, nor the number of axons in a nerve bundle. Post-synaptic response to spontaneous vesicle release is normal. The phenotype is more severe for the A6 segment than the A2 segment demonstrating a correlation between severity of phenotype and axon length.

      (Gho et al., 1992)

      Larval growth abnormalities and lack of mobility.

      (Saxton et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Khc5 is an enhancer of phenotype of parats1

      (Hurd et al., 1996)

      Khc5 is an enhancer of phenotype of mlenap-ts1

      (Hurd et al., 1996)
      Suppressor of
      Statement
      Reference

      Khc5 is a suppressor of phenotype of Sh14

      (Hurd et al., 1996)

      Khc5 is a suppressor of phenotype of eag1

      (Hurd et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Khc5/Khc4 is rescued by Khc+t7.5

      (Hurd et al., 1996)

      Khc5 is rescued by Khc+t7.5

      (Saxton et al., 1991)
      Comments

      The paralysis of Khc4/Khc5 flies at 39oC is rescued by one copy of Khc+t7.5.

      (Hurd et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Khc5
      Name Synonyms
      Secondary FlyBase IDs
        References (3)