FlyBase Allele Report: Dmel\Usp47[Evar1]

General Information

Symbol

Dmel\Usp47^Evar1

Species

D. melanogaster

Name

FlyBase ID

FBal0029663

Feature type

allele

Associated gene

Dmel\Usp47

Associated Insertion(s)

P{lArB}Usp47^Evar1

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Henchoz et al., 1996, Dorn et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{lArB}Usp47^Evar1

Cytology

Description

P{lArB} insertion 2kb 5' from the start of transcription.

(Henchoz et al., 1996)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation | dominant, with In(1)w^m4h

(Henchoz et al., 1996, Dorn et al., 1993)

Phenotype Manifest In

eye

(Henchoz et al., 1996)

medial row of triple row of wing sensilla

(Henchoz et al., 1996)

ommatidium

(Henchoz et al., 1996)

testis

(Henchoz et al., 1996)

Detailed Description

Statement

Reference

Enhances the mottled eye phenotype of In(1)w^m4h so the eye is almost completely white and testes show patches of colourless tissue. Colourless phenotype can be suppressed by Su(var)2-1¹. Regions of ommatidial disorganisation are sometimes observed within white areas (interpreted as inactivation of the rst locus, located more distally that w on the In(1)w^m4h rearrangement). Enhances the y variegated phenotype of Dp(1;f)1187, a higher percentage of yellow bristles are observed on the medial triple row at the anterior wing margin. Visible phenotype of Pc²³ or Df(3R)red-P52 is not altered in the presence of Ubp64E^Evar1.

(Henchoz et al., 1996)

Enhances variegation of In(1)w^m4h.

(Dorn et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Usp47^Evar1 has phenotype, suppressible by Su(var)2-1¹

(Henchoz et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

G. Reuter.

(Henchoz et al., 1996)

Comments

Weak enhancer. High spontaneous background rate of E(var) mutations in these experiments allows for the possibility that the P insertion is not the cause of the E(var) phenotype.

(Dorn et al., 1993)

Mobilisation of the P{lArB} insertion reverts the enhancer phenotype linking the presence of the insertion to the enhancer phenotype.

(Henchoz et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

D-UBP-64E^Evar1

(Henchoz et al., 1996)

E(var)1¹

Ubp64E^Evar1

Usp47^Evar1

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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