FlyBase Allele Report: Dmel\e(r)[p1]

General Information

Symbol

Dmel\e(r)^p1

Species

D. melanogaster

Name

FlyBase ID

FBal0021162

Feature type

allele

Associated gene

Dmel\e(r)

Associated Insertion(s)

P{}e(r)^p1

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wojcik et al., 1994)

Mutagen

PM hybrid dysgenesis

(Wojcik et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{}e(r)^p1

Cytology

Description

Insertion of a 1.1kb P-element in the first exon, upstream of the translation start site. The P-element is oriented in the same orientation as the e(r) gene.

(Close and Tsubota, 2004)

P-element insert in the 5' untranslated leader region near the start of transcription.

(Wojcik et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,906,127..8,906,134 [-]

(Close and Tsubota, 2004, Wojcik et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Close and Tsubota, 2004)

viable

(Close and Tsubota, 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

In a wild type r background e(r)^p1 does not display a mutant wing phenotype.

(Wojcik et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

e(r)^p1 is an enhancer of visible phenotype of r^hd1-12

(Gelsthorpe et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

e(r)^p1 is an enhancer of wing phenotype of r^hd1-12

(Gelsthorpe et al., 2006, Close and Tsubota, 2004)

e(r)^p1 is an enhancer of wing phenotype of r^hd1

(Wojcik et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Recessive enhancer of a weak r mutant phenotype, enhances wing truncation.

(Wojcik et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

e(r)^p1 is rescued by e(r)^+t6.2

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T18A

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T18E

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^S24E

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^E27Q

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T63A

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T63E

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T18A.T63A

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^T18E.T63E

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^S24E.T63E

(Gelsthorpe et al., 2006)

e(r)^p1 is rescued by e(r)^+t6.2

(Wojcik et al., 1994)

Not rescued by

e(r)^p1 is not rescued by e(r)^T18A.S24A

(Gelsthorpe et al., 2006)

e(r)^p1 is not rescued by e(r)^T18E.S24E

(Gelsthorpe et al., 2006)

e(r)^p1 is not rescued by e(r)^{T18A.S24A.T63A}

(Gelsthorpe et al., 2006)

e(r)^p1 is not rescued by e(r)^{T18E.S24E.T63E}

(Gelsthorpe et al., 2006)

e(r)^p1 is not rescued by e(r)^t7.9stop

(Wojcik et al., 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

P-element has been precisely excised and imprecisely excised resulting in an 89bp insertion at the original insertion site.

(Wojcik et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

e(r)^p1

(Roykhman et al., 2007, Gelsthorpe et al., 2006, Close and Tsubota, 2004)

r^hd1-16

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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