FB2024_03 , released June 25, 2024
Allele: Dmel\z11G3
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General Information
Symbol
Dmel\z11G3
Species
D. melanogaster
Name
FlyBase ID
FBal0018825
Feature type
allele
Associated gene
Dmel\z
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Chen and Pirrotta, 1993)
Mutagen
X ray
(Mariani et al., 1985)
Progenitor genotype
z1
(Chen et al., 1992, Bickel and Pirrotta, 1990, Mariani et al., 1985)
Cytology

Polytene chromosomes normal.

Description

Deletion of Y amino acid from residue 510.

(Chen and Pirrotta, 1993)

The nucleotides encoding amino acid residue Tyr-510 are deleted.

(Chen et al., 1992)

Amino acid replacement: K425M. Amino acid 510 (tyrosine) is deleted.

(Bickel and Pirrotta, 1990)

The sequence of z11G3 is identical to that of z1 except that three nucleotides have been deleted, removing a tyrosine from the amino acid sequence (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:2,450,007..2,450,009 [+]
Comment:

Tyrosine 510 is deleted in z11G3. Induced on z1 chromosome so also carries the K425M amino acid change.

(Bickel and Pirrotta, 1990, Pirrotta et al., 1987)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye colour: red in male and female.

      (Chen and Pirrotta, 1993)

      Partial revertant of z1.

      (Mariani et al., 1985)

      Eye colour: wild-type as hemizygous male and homozygous female.

      (Gans, 1953)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      z11G3 is a non-enhancer of sex comb phenotype of ScrWrv4/ScrTpl9

      (Southworth and Kennison, 2002)

      z11G3 is a non-enhancer of sex comb phenotype of ScrAntp-A41/ScrTpl9

      (Southworth and Kennison, 2002)

      z11G3 is a non-enhancer of sex comb phenotype of ScrTpl9

      (Southworth and Kennison, 2002)
      NOT Suppressor of
      Statement
      Reference

      z11G3 is a non-suppressor of sex comb phenotype of ScrWrv4/ScrTpl9

      (Southworth and Kennison, 2002)

      z11G3 is a non-suppressor of sex comb phenotype of ScrAntp-A41/ScrTpl9

      (Southworth and Kennison, 2002)

      z11G3 is a non-suppressor of sex comb phenotype of ScrTpl9

      (Southworth and Kennison, 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The average number of sex comb teeth per first leg in ScrTpl9 heterozygous males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying za. The average number of sex comb teeth per first leg in ScrTpl9/ScrAntp-A41 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying za. The viability and average number of sex comb teeth per first leg in ScrTpl9/ScrWrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfdrv1) is not affected if they are also carrying za.

      (Southworth and Kennison, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      z1

      (Gans, 1953)
      Comments

      Mapped to z, rather than to w by Judd.

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Gans.

      Revertant. \partial

      Comments
      Comments

      Does not support transvection at dpp or Ubx.

      Unable to promote transvection at dpp and Ubx.

      (Bickel and Pirrotta, 1990)

      The phenotype of Abd-Biab7-MX2/Abd-Biab8-D14 is unaffected by alleles of z.

      (Hendrickson and Sakonju, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      w11G3
      z11G3
      Name Synonyms
      Secondary FlyBase IDs
        References (13)