FB2024_02 , released April 23, 2024
Allele: Dmel\y1
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General Information
Symbol
Dmel\y1
Species
D. melanogaster
Name
FlyBase ID
FBal0018607
Feature type
allele
Associated gene
Dmel\y
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Georgiev and Corces, 1995, Geyer et al., 1990)

loss of function allele

(Drapeau et al., 2006)
Mutagen
spontaneous
(Morris et al., 1999)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Campuzano et al., 1985)
Description

Known mutation in sequenced strain: single base change in start codon (see FBrf0051634).

(FlyBase Curators, 2002-)

Deletion of the y promoter, not enhancer.

(Georgiev and Kozitsina, 1992)

A to C tranversion in the ATG translation initiation codon.

(Geyer et al., 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:356,680..356,680 [+]
Comment:

A to C tranversion in the ATG translation initiation codon. The reference sequence strain, iso-1, carries the y1 mutation.

(Geyer et al., 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      y1 individuals have a 'yellow' body color; the sex combs show reduced melanization and the sex comb teeth appeared thinner and smoother than in controls; the aedeagus show no melanization defects.

      y1 males show severely reduced mating success when paired with wild-type females: copulation initiation is reduced, but there are no significant changes in courtship behavior (courtship time or wing extension bouts) or courtship song (pulse frequency, sine frequency or inter pulse interval), as compared to controls. This defect is not observed when y1 females are paired with wild-type males or when y1 males are paired with y1 females.

      (Massey et al., 2019)

      y1/y1#8 females have a completely null y[-] pigmentation phenotype in the wings and in the body.

      The presence of Dp(1;2)y2A increases pigmentation in both the body and wing cuticle in y1/y1#8 females.

      (Ou et al., 2009)

      y1 males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y1 adults lack pigmentation throughout the body, the wings, bristles, aristae and tarsal claws. The sex combs of y1 males have a lighter colour than wild type.

      (Drapeau et al., 2006)

      Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): homozygote: 1 (wing), 1 (body), hemizygote: 1 (wing), 1 (body), y1/yeve-tata : 2 (wing), 2-3 (body), y1/yhsp70-tata : 4-5 (wing), 4+-5 (body), y1/yw-DPE26 : 4 (wing), 4 (body), y1/yw-DPE29 : 2 (wing), 1+-2 (body), y1/yeve-tata-1 : 1 (wing), 1 (body), y1/yhsp70-tata-1 : 1 (wing), 1 (body), y1/yw-DPE26-1 : 1 (wing), 1 (body), y1/yw-DPE29-1 : 1 (wing), 1 (body), y1/yP1\loxP.eve-700gin : 2+-3 (wing), 2+ (body), y1/yP1\loxP.hsp70-700gin : 5 (wing), 4+-5 (body), y1/yP1\loxP.w-700gin : 2+-3 (wing), 2+ (body).

      (Lee and Wu, 2006)

      Males have a reduced wing extension index (the percentage of each courtship ritual during which a male's wing is extended and vibrating) compared to wild type.

      (Drapeau et al., 2003)

      A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. I y1 mutants the black melanin is lost from the stripes leaving a brown pigment. The cuticle anterior to the stripe has a tan appearance relative to wild-type. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan.

      (Wittkopp et al., 2002)

      Homozygous y+s7 or y2s14 females have a stronger mutant phenotype than y+s7/y1 or y2s14/y1 females in the presence of ph-pP1.

      (Belenkaya et al., 1998)

      The pigmentation induced in unpigmented y1 pharate adult tissue by incubation with dopamine in vitro closely resembles the y1 phenotype, producing brown pigmentation in all cuticle structures.

      (Walter et al., 1996)

      Body colour: no pigmentation.

      (Georgiev and Corces, 1995)

      Body colour: yellow; hairs & bristles brown with yellow tips; wing veins, wing hairs, yellow. Larval mouth part colour: yellow-brown. Larval denticle belt colour: yellow-brown.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      y[+]/y1 is an enhancer of chemical sensitive phenotype of Gk1RNAi.UAS, Scer\GAL4c564

      (Wightman et al., 2012)
      Suppressor of
      Statement
      Reference

      y1 is a suppressor | partially of abnormal body color phenotype of Ask1ΔN.UAS.Tag:FLAG, Scer\GAL4pnr-MD237

      (Sekine et al., 2011)
      Other
      Statement
      Reference

      e1, y1 has abnormal body color phenotype

      (Wittkopp et al., 2002)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      y1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Suppressor of
      Statement
      Reference

      y1 is a suppressor | partially of adult thorax phenotype of Ask1ΔN.UAS.Tag:FLAG, Scer\GAL4pnr-MD237

      (Sekine et al., 2011)

      y1 is a suppressor of phenotype of svrpoi-Ca

      Other
      Statement
      Reference

      e1, y1 has adult cuticle phenotype

      (Wittkopp et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The glycerol hypersensitivity of flies expressing GykdsRNA.Scer\UAS under the control of Scer\GAL4c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for y1.

      (Wightman et al., 2012)

      In a y1 hemizygous background, pigmentation in the thorax of Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 flies is brown rather than black, particularly in the scutellum.

      (Sekine et al., 2011)

      A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment.

      (Wittkopp et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      y2

      (Chen et al., 2002)

      y3c3

      (Morris et al., 1999)

      y82f29

      (Morris et al., 1999)

      y2374

      (Morris et al., 1999)

      y62a

      (Morris et al., 1999)

      y59b

      (Morris et al., 1999)

      y2

      (Morris et al., 1999)
      Rescued by

      y1 is rescued by yUAS.cCa/Scer\GAL4dsx-GAL4

      (Massey et al., 2019)

      y1 is rescued by Scer\GAL4dsx.KI/yUAS.cCa

      (Massey et al., 2019)

      y1 is rescued by yUAS.cCa/Scer\GAL4c81

      (Drapeau et al., 2003)

      y1 is rescued by yUAS.cCa/Scer\GAL4Act5C.PI

      (Drapeau et al., 2003)
      Partially rescued by

      y1 is partially rescued by yUAS.cCa/Scer\GAL80nSyb.PS/Scer\GAL4dsx-GAL4

      (Massey et al., 2019)

      y1 is partially rescued by yUAS.cCa/Scer\GAL4y.PG

      (Massey et al., 2019)
      Not rescued by

      y1 is not rescued by Scer\GAL4fru.P1.D/yUAS.cCa

      (Massey et al., 2019)
      Comments

      The expression of yUAS.cCa under the control of Scer\GAL4y.PG suppresses the yellow body color but not the male mating defects of y1 mutants.

      The expression of yUAS.cCa under the control of Scer\GAL4dsx-GAL4 alone or under the combined control of Scer\GAL4dsx-GAL4 and Scer\GAL80nSyb.PS fully and partially rescues, respectively, the male mating defects of y1 mutants.

      The expression of yUAS.cCa under the control of Scer\GAL4dsx.KI rescues both the body color and male mating defects of y1 mutants.

      (Massey et al., 2019)

      Flies carrying yΔ1A-2.w-hs.Scer\SceI.RS or yΔ1A-2.Δ1A-2'.w-hs.Scer\SceI.RS in a y1 background have dark pigmentation of all cuticle structures except the wing.

      (Soshnev et al., 2008)
      Images (1)
      Stocks (62,202)
      Notes on Origin
      Discoverer

      E.M. Wallace, Jan. 1911.

      Comments
      Comments

      Marker mutation present in the strain used in the genome sequencing project.

      (Misra et al., 2002)

      y2 promoter causes trans-activation of enhancer.

      (Georgiev and Kozitsina, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (64)