FB2024_02 , released April 23, 2024
Allele: Dmel\y1#8
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General Information
Symbol
Dmel\y1#8
Species
D. melanogaster
Name
FlyBase ID
FBal0036033
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Cytology
Description

Deletion of 0.8kb. 17bp of P-element sequence remain at the deletion breakpoints.

Imprecise excision of a P-element inserted in the promoter of the progenitor, resulting in a deletion of y sequences from -716bp to +66bp including the TATA box.

Complete excision of the P-element from the 5' untranslated region and deletion of the TATA box and transcription initiation site.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous females, hemizygous females and hemizygous males have a completely null y[-] pigmentation phenotype in the wings and in the body.

y2/y1#8 females show nearly wild-type pigmentation levels in the wing and body.

y1/y1#8, y1#8/y1BC;28C, y1#8/T(1;3)YTD1, y1#8/In(1)1BC;9B;20 and y1#8/T(1;2)1BC;11-12;20;51 females have a completely null y[-] pigmentation phenotype in the wings and in the body.

y1#8/Tp(3;1)YTD2, y1#8/T(1;2)YTD3 and y1#8/T(1;2;3)YTD4 females have low pigmentation in the wings and in the body.

y1#8/T(1;2;3)YTD5 females show have a null y[-] pigmentation phenotype in the wings and in the body, although the bristle pigmentation is variegated, ranging from dark to light.

y1#8/T(1;4)1BC;102DF females show a null y[-] pigmentation phenotype in the body, whereas pigmentation in the wing is less defective.

y1#8/T(1;2;3)1BC;40-41A;98CE females show a null y[-] pigmentation phenotype in the wing, whereas pigmentation in the body is less defective. The bristle pigmentation is variegated, ranging from dark to light.

Dp(1;2)y2A reduces the level of complementation that is normally observed between y1#8 and y2 (the progenitor of Dp(1;2)y2A), such that the body and wing cuticle of y1#8/Dp(1;2)y2A females has a more severe pigmentation phenotype than that of y1#8/y2 females.

The presence of Dp(1;2)y2A increases pigmentation in both the body and wing cuticle in y1/y1#8 and y1#8/y1#8 females.

Dp(1;2)y2A strongly increases pigmentation in both the body and wing cuticle in y1#8 hemizygous females.

Hemizygous y1#8/Y males carrying one copy of Dp(1;2)y2A have dark pigmentation, while hemizygous y1#8/Y males carrying two copies of Dp(1;2)y2A have light pigmentation.

Dp(1;4)y2B reduces the level of complementation that is normally observed between y1#8 and y2 (the progenitor of Dp(1;4)y2B), such that the body and wing cuticle of y1#8/Dp(1;4)y2B females has a more severe pigmentation phenotype than that of y1#8/y2 females.

Dp(1;4)y2C reduces the level of complementation that is normally observed between y1#8 and y2 (the progenitor of Dp(1;4)y2C), such that the body and wing cuticle of y1#8/Dp(1;4)y2C females has a more severe pigmentation phenotype than that of y1#8/y2 females.

The presence of Dp(1;4)y2B increases pigmentation in both the body and wing cuticle in y1#8/y1#8 females.

The presence of Dp(1;4)y2C increases pigmentation in both the body and wing cuticle in y1#8/y1#8 females.

Body colour: y1#8/y82f29 flies show partial cuticle pigmentation.

Body colour: pigmentation score (where 1 = null/nearly null, 5 = wild type/nearly wild type): y1#8/yP1\loxP.eve-700gin : 4-4+ (wing), 4-4+ (body), y1#8/yP1\loxP.hsp70-700gin : 5 (wing), 5+ (body), y1#8/yP1\loxP.w-700gin : 4 (wing), 4 (body).

Body colour: y1#8 in transheterozygous combination with yTD82f-1, yTD82f-2, yTD82f-3, yTD82f-4, yTD82f-5, yTD82f-6

or yTD82f-7 results in flies with a pigmentation score of 1 (where

1 = absence of y expression and 5 = wild type) in both the body and

wing.

Body colour: yTD82f-8/y1#8 flies have a pigmentation score

of 1 in the wing and 2 in the body.

Body colour: yTD82f-9/y1#8 flies have a pigmentation score

of 2 in both the body and wing.

Body colour: y82f29/y1#8 flies have a pigmentation score of

3 in both the body and wing.

Body colour: y1#8 in transheterozygous combination with yTD2-9,

yTD2-8, yTD2-7, yTD2-6, yTDF-1 or yTDF-2 results

in flies with a pigmentation score of 1 in both the body and wing.

Body colour: y1#8 in transheterozygous combination with yTD2-5,

yTD2-4 or yTD2-3 results in flies with a pigmentation score

of 3 in the wing and 2-3 in the body.

Body colour: y1#8 in transheterozygous combination with yTD2-2,

yTD2-1 or yTDF results in flies with a pigmentation score of

4 in both the body and wing.

Body colour: y2/y1#8 flies have a pigmentation score of 4 in

both the body and wing.

Body colour: y1#8 in transheterozygous combination with yTDH+165,

yTDH+161, yTDH+105, yTDH+51, yTDH+48, yTDH+36,

yTDH+1, yTDH-4b, yTDH-28c, yTDH-46, yTDH-55, yTDH-59

or yTDH-80 results in flies with a pigmentation score of 1 in both

the body and wing.

Body colour: y1#8 in transheterozygous combination with yTDH-98,

yTDH-99, yTDH-108 or yTDH-116 results in flies with a pigmentation

score of 1-2 in the wing and 1 in the body.

Body colour: y1#8 in transheterozygous combination with yTDH-162,

yTDH-163, yTDH-166, yTDH-169, yTDH-172, yTDH-231,

yTDH-244b, yTDH-288, yTDH-321, yTDH-363, yTDH-370,

yTDH-376, yTDH-385, yTDH-442, yTDH-470, yTDH-479b,

yTDH-490, yTDH-499, yTDH-586, yTDH-743a, yTDH-743b,

yTDH-743c or yTDH-743d results in flies with a pigmentation

score 2 or 3 in the wing and 1-2 or 2 in the body.

Body colour: y1#8 in transheterozygous combination with yTDH-158,

yTDH-641 or yTDH-1039 results in flies with a pigmentation

score of 2 in the wing and 1-2 in the body.

Body colour: y1#8 in transheterozygous combination with yTDH-178

or yTDH-786 results in flies with a pigmentation score of 2-3 in

the wing and 1-2 in the body.

Body colour: yTDH-981/y1#8 flies have a pigmentation score

of 2-3 in the wing and 1-2 in the body.

Body colour: yTDH-1061/y1#8 flies have a pigmentation score

of 2-3 in the wing and 2 in the body.

Body colour: yTDH-1111/y1#8 flies have a pigmentation score

of 3 in the wing and 2 in the body.

Body colour: yTDH-1142/y1#8 flies have a pigmentation score

of 2-3 in the wing and 2 in the body.

Body colour: yTDH-1491/y1#8 flies have a pigmentation score

of 3 in the wing and 2-3 in the body.

Body colour: yTDH-1583/y1#8 flies have a pigmentation score

of 2-3 in the wing and 3 in the body.

Body colour: yTDH-1683/y1#8 flies have a pigmentation score

of 3 in the wing and 3-4 in the body.

Body colour: yTDH-1872/y1#8 flies have a pigmentation score

of 3 in the wing and 3-4 in the body.

Body colour: yTDH-1924/y1#8 flies have a pigmentation score

of 4 in the wing and 5 in the body.

Body colour: yTDH-2097/y1#8 flies have a pigmentation score

of 5 in the wing and 5 in the body.

Body colour: yTDH-2491/y1#8 flies have a pigmentation score

of 5 in the both the wing and body.

Body colour: yTDH-2576/y1#8 flies have a pigmentation score

of 5 in the both the wing and body.

y1#8/y2 show a y+ phenotype which is completely suppressed by mod(mdg4)ul.

Same phenotype as y1.

like y1

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Body colour: The reduced body pigmentation seen in y1#8/y82f29 flies is partially suppressed by Cap-H2Z3-0019/Df(3R)Exel6159.

The presence of sc[D1] in y2 scD1/y1#8 flies abolishes interallelic complementation. y2 scD1/y1#8 females show weak pigmentation of the body and wings.

The presence of sc[D1h33] in y2 scD1h33/y1#8 flies abolishes interallelic complementation. y2 scD1h33/y1#8 females show weak pigmentation of the body and wings.

y2 sc+1MC/y1#8 females show the same wild-type like pigmentation phenotype as y2/y1#8 heterozygotes.

y2 sc+2MC/y1#8 females show the same wild-type like pigmentation phenotype as y2/y1#8 heterozygotes.

y2 scR1/y1#8 females show the same wild-type like pigmentation phenotype as y2/y1#8 heterozygotes.

y2 scR2/y1#8 females show the same wild-type like pigmentation phenotype as y2/y1#8 heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Green.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0018611
References (16)