FlyBase Allele Report: Dmel\w[ch]

General Information

Symbol

Dmel\w^ch

Species

D. melanogaster

Name

cherry

FlyBase ID

FBal0018224

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

pogo{}w^ch

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

Mutagen

spontaneous

(Zachar and Bingham, 1982)

Progenitor genotype

w¹

(Larsson et al., 1996)

Associated Insertion(s)

pogo{}w^ch

Cytology

Polytene chromosomes normal.

(Larsson et al., 1996)

Description

pogo insertion into Doc of w¹.

(Larsson et al., 1996)

0.2 kb pogo insertion in Doc element map site (kb): +3.71; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Lloyd et al., 2002)

abnormal eye color | recessive

visible | recessive

Phenotype Manifest In

Malpighian tubule

ocellus pigment granule

pigment cell

(Lloyd et al., 2002, Montell et al., 1992, Zachar and Bingham, 1982)

testis pigment cell

Detailed Description

Statement

Reference

Homozygotes have pink-orange eyes with only 2% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Eye colour: pinkish.

(Montell et al., 1992)

Eye colour: light yellow-pink.

(Zachar and Bingham, 1982)

Eye colour: translucent pink; male lighter than female. Eye colour: light, with rb¹. Eye colour: light, with g¹. Eye colour: white, when heterozygous with w^a. Ocellus colour: pale. Testis colour: colourless. Malpighian tubule colour: colourless.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

w^ch/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

w^ch/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^ch has phenotype, enhanceable by e(w^e)¹

(O'Hare, 1991)

w^ch has phenotype, enhanceable by Pale¹

Suppressed by

Statement

Reference

w^ch has phenotype, suppressible by Su(w^ch)¹

(O'Hare, 1991, Safir, 1913)

NOT suppressed by

Statement

Reference

w^ch has phenotype, non-suppressible by east¹

(Chapman and Bingham, 1985)

Enhancer of

Statement

Reference

w^ch/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

w^ch/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w^ch/w^e(g) mutant genotype enhance the eye colour defective phenotype of g² and g^50e homozygous mutants leading to a greater reduction of red pigment in the eye. Male w^ch, g^53d double mutant flies have lower levels of pigment in the eye than w^ch single mutants, leading to a change in eye colour from faint pink-orange to completely white.