FB2024_03 , released June 25, 2024
Allele: Dmel\ush1
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General Information
Symbol
Dmel\ush1
Species
D. melanogaster
Name
FlyBase ID
FBal0017648
Feature type
allele
Associated gene
Dmel\ush
Associated Insertion(s)
Carried in Construct
Also Known As
ushl(2)19
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Biryukova and Heitzler, 2008, Cubadda et al., 1997)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ush1 homozygous embryos are U-shaped.

      (Biryukova and Heitzler, 2008)

      Mutant embryos show an significant increase in the average number of crystal cells (of about 30%) as compared to wild-type.

      (Fossett et al., 2001)

      Homozygous mutant embryos at stage 11 show an increase in cardial cells seen per segment, a few hemisegments contain nine cells with an average of six present in many clusters (as compared to the four seen per hemisegment in wild-type). At stage 13, embryos possess supernumerary cardioblast nuclei - up to 12 nuclei per hemisegment with 8 cells per cluster on average. There is also an increase in the number of eve expressing pericardial cells seen - from three per cluster in wild-type, to 5-6 per cluster in homozygous mutants. There also appears to be a defect in mesodermal cell migration. Embryos display an irregular layer where mesodermal cells remain clustered and fail to undergo their complete dorsal migration.

      (Fossett et al., 2000)

      strong embryonic lethal No shortening of the germ band. Lateral fusion of anterior and posterior hypoderm.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos heterozygous for htlAB42 and ush1 show a strong mesodermal migration defect. Also about half show a loss of cells from the dorsal mesoderm.

      (Fossett et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Both midgut primordia extend normally along the visceral mesoderm and the yolk is completely engulfed by the endoderm.

      (Reuter et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ush19
      (Reuter et al., 1993, Tearle and Nusslein-Volhard, 1987)
      ush1
      (Muratoglu et al., 2007)
      ushl(2)19
      (Biryukova and Heitzler, 2008, Cubadda et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)