FB2024_03 , released June 25, 2024
Allele: Dmel\tup2
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General Information
Symbol
Dmel\tup2
Species
D. melanogaster
Name
FlyBase ID
FBal0017280
Feature type
allele
Associated gene
Dmel\tup
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Biryukova and Heitzler, 2005)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Biryukova and Heitzler, 2005)

The G to A mutation is in the AG acceptor splice site of the second intron.

(Biryukova and Heitzler, 2005)

This mutation is predicted to result in a severely truncated protein.

(Biryukova and Heitzler, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:18,864,524..18,864,524 [-]
Nucleotide change:

G18864524A

Reported nucleotide change:

G?A

Comment:

G to A mutation in the AG acceptor splice site of the second intron.

(Biryukova and Heitzler, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tupJQ3 fails to complement tup2 as judged by the increase in scutellar macrochaetae.

      (de Navascués and Modolell, 2010)

      Homozygous clones in the lateral-posterior region of the notum can result in ectopic structures, such as ectopic sclerites and an ectopic tegula-like structure, bearing macrochaetae and sensilla trichoidea. Homozygous clones can also result in protrusions of the notum cuticle and also to small, tubercle-like disruptions with a corrugated appearance and roundish contour.

      (de Navascués and Modolell, 2007)

      tup2 die as embryos with a prominent dorsal hole.

      (Biryukova and Heitzler, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      tup[+]/tup2 is an enhancer of thorax phenotype of ChiE

      (Biryukova and Heitzler, 2005)

      tup[+]/tup2 is an enhancer of scutellar bristle | increased number phenotype of ChiE

      (Biryukova and Heitzler, 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      tup2 enhances the excess scutellar bristle and thoracic cleft phenotype of ChiE flies when heterozygous.

      (Biryukova and Heitzler, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      tupJQ3 fails to complement tup2 as judged by the increase in scutellar macrochaetae.

      (de Navascués and Modolell, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Both midgut primordia extend normally along the visceral mesoderm and the yolk is completely engulfed by the endoderm.

      (Reuter et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      islIIIE16
      (Biryukova and Heitzler, 2005)
      tup2
      (de Navascués and Modolell, 2010, de Navascués and Modolell, 2007)
      tupIIIE
      (Reuter et al., 1993, Tearle and Nusslein-Volhard, 1987)
      tupIIIe
      Name Synonyms
      Secondary FlyBase IDs
        References (6)