FB2024_03 , released June 25, 2024
Allele: Dmel\tld1
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General Information
Symbol
Dmel\tld1
Species
D. melanogaster
Name
FlyBase ID
FBal0016872
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Also Known As
tld5H
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Childs and O'Connor, 1994, Finelli et al., 1994)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: M487H. Nucleotide substitution: T1460A.

(Childs and O'Connor, 1994)

The mutation falls in the C2 domain of the tld protein.

(Finelli et al., 1994)

Amino acid replacement: M487K.

(Finelli et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,751,597..24,751,597 [+]
Nucleotide change:

T24751597A

Reported nucleotide change:

T?A

Amino acid change:

M497K | tld-PA

Reported amino acid change:

M487K

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Finelli et al., 1994)
point_mutation
3R:24,751,597..24,751,597 [+]
Nucleotide change:

T24751597A

Reported nucleotide change:

T1460A

Amino acid change:

M497K | tld-PA

Reported amino acid change:

M487K

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Childs and O'Connor, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tldMBT/tld1 hybrids have rough eyes at the permissive temperature. At the restrictive temperature, 30% die as pupae. The optic lobes are not hyperplastic, brain cells are differentiated but do not adhere. Pupal lethal when heterozygous with the MBT chromosome. Ubiquitous neoplasm/melanomes are seen.

      (Riede, 2001)

      Antagonistic activity towards dpp.

      (Childs and O'Connor, 1994)

      Weak ventralization.

      (Finelli et al., 1994)

      Weak ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

      (Arora and Nusslein-Volhard, 1992)

      weak embryonic lethal Partially ventralized. Cephalic furrow shifted dorsally; defects in germband extension. Denticle belts extended laterally.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      tld1/tld14 has lethal phenotype, suppressible by sogY506

      (Ferguson and Anderson, 1992)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Weak phenotype can be completely suppressed by a duplication of dpp+.

      (Ferguson and Anderson, 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tldMBT

      (Riede, 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Very weak tld allele.

      (Ferguson and Anderson, 1992)

      Weak, incompletely penetrant tld allele. Allelic series for tld antagonistic effect on dpp : tldB3 > tld14 = tld6 > tld1 > tld6P41 > tld9Q19.

      (Childs and O'Connor, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (6)