FB2024_03 , released June 25, 2024
Allele: Dmel\SxlfPb
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General Information
Symbol
Dmel\SxlfPb
Species
D. melanogaster
Name
FlyBase ID
FBal0016696
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
P{}SxlfPb
Carried in Construct
Key Links
Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lindsley and Zimm, 1992)

loss of function allele

(Maine et al., 1985)
Mutagen
spontaneous
(Lindsley and Zimm, 1992)
PM hybrid dysgenesis
(Lindsley and Zimm, 1992)
Progenitor genotype
Associated Insertion(s)
P{}SxlfPb
Cytology
Description

P element insertion.

(Lindsley and Zimm, 1992)

Insertion of P-element on the 5' side of the gene, at coordinate 0 (coordinates according to FBrf0042036).

(Salz et al., 1987)

Insertion of P-element into the Sxl gene.

(Maine et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A P-insertion-induced lethal hypomorphic allele with the unusual distinction of displaying a mosaic intersex phenotype in homozygous mutant diplo-X clones induced by mitotic recombination; hence, appears to be defective in the cellular maintenance of the female sexual commitment. Under dysgenic conditions, can mutate further to less extreme or to more extreme condition. Partially complements Sxlf7,M1, generating masculinized individuals; partially complements Sxlf2593, generating sterile females; fully complements Sxlf9.

      (Lindsley and Zimm, 1992)

      Partial loss-of-function allele. Only partially complemented by Sxlf7,M1. Fully complements Sxlf9 and Sxlf2. Homozygous germline clones develop normally.

      (Salz et al., 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      SxlfPb is a non-suppressor of decreased fecundity | dominant | female phenotype of ovoD2

      (Oliver et al., 1990)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The number of vitellogenic eggs produced by ovoD2 heterozygous females is not increased by SxlfPb.

      (Oliver et al., 1990)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Nuclei of SxlfPb/Sxlf2593 larvae exhibit binding of the msl gene products to the paired X chromosomes but no Sxl binding.

      (Hilfiker et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SxlfPb
      Name Synonyms
      Secondary FlyBase IDs
        References (7)