FB2024_03 , released June 25, 2024
Allele: Dmel\svp2
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General Information
Symbol
Dmel\svp2
Species
D. melanogaster
Name
FlyBase ID
FBal0016609
Feature type
allele
Associated gene
Dmel\svp
Associated Insertion(s)
Carried in Construct
Also Known As
svpe300
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Fanto et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      svp1/svp2 embryos have extra U1 neurons at the expense of later born U neurons from the same (NB7-1) lineage. U4 and U5 neurons are particularly depleted. Similarly, there are increased numbers of early born cells from the NB 7-3 lineage (EW1) compared to later born cells from this lineage (EW2 and EW3).

      (Kanai et al., 2005)

      When one cell of the R3/R4 pair is mutant in mosaic ommatidia in homozygous clones in the eye, the ommatidium adopts the wrong chiral form and the svp- cell assumes the R4 position. Mosaic ommatidia with mutant R1 or R6 cells behave normally.

      (Fanto et al., 1998)

      embryonic lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      svp2/svp1 has EW2 neuron phenotype, enhanceable by KrmCD, Kr1/Kr1

      (Kanai et al., 2005)

      svp2/svp1 has EW3 neuron phenotype, enhanceable by KrmCD, Kr1/Kr1

      (Kanai et al., 2005)

      svp2/svp1 has larval DA3 motor neuron phenotype, enhanceable by KrmCD, Kr1/Kr1

      (Kanai et al., 2005)

      svp2/svp1 has larval LL1 motor neuron phenotype, enhanceable by KrmCD, Kr1/Kr1

      (Kanai et al., 2005)
      Suppressed by
      Statement
      Reference

      Kr1, KrmCD, svp2/svp1 has EW3 neuron phenotype, suppressible | partially by hb15/hb12

      (Kanai et al., 2005)

      Kr1, KrmCD, svp2/svp1 has larval DA3 motor neuron phenotype, suppressible | partially by hb15/hb12

      (Kanai et al., 2005)

      Kr1, KrmCD, svp2/svp1 has larval LL1 motor neuron phenotype, suppressible | partially by hb15/hb12

      (Kanai et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      KrmCD; Kr1/Kr1 enhances the reduction in later born neurons of the NB7-1 an NB2-3 lineages see in svp1/svp2 embryos so that U4 and U5 are almost completely eliminated, as are EW2 and EW3. This enhanced phenotype is partially suppressed if the embryos are also hb12/hb15.

      (Kanai et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      e300
      (Mlodzik et al., 1990)
      e300
      (Gausz et al., 1981)
      l(3)ck16e300
      svp2
      svpe300
      (Kanai et al., 2005, Fanto et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)